冠心病患者C反应蛋白测定的临床意义

目的　探讨急性炎症反应和急性冠状动脉综合征之间的关系。方法　测定 4 2例冠心病患者和 2 0例正常健康成人 (NCHD)血清的C 反应蛋白 (CRP)。冠心病患者又分为 3组 ,稳定型心绞痛 (SAP)组 17例 ,不稳定型心绞痛 (UAP)组 12例 ,急性心肌梗死 (AMI)组 13例。比较SAP组与NCHD组之间 ,UAP组、AMI组与NCHD组之间CRP的差异。结果UAP组、AMI组的CRP水平明显高于NCHD组 (分别为 :P <0 0 0 5、P <0 0 0 0 1) ,但SAP组与NCHD组的CRP水平无明显差异。结论　急性心肌梗死与不稳定型心绞痛均系急性冠状动脉综合征 ,提示急性炎症参与急性冠状动脉综合征的发病过程

Clinical Significance of C-reactive Protein Measurement in Patients with Coronary Artery Disease

Objective To investigate the relationship between acute inflammation and acute coronary artery syndromes. Method To measure the levels of C reactive protein(CRP) in 42 patients with coronary heart disease and 20 persons with non coronary heart disease.The patients with coronary heart disease were divided into three groups.17 cases of stable angina pectoris (SAP group),12 cases of unstable angina pectoris (UAp group),13 cases of acute myocardial infarction(AMI group).To compare the difference of the levels of C reactive protein between SAP group and NCHD group,between UAP group,AMI group and NCHD group. Result The levels of C-reactive protein in UAP group and AMI group were higher than those in NCHD group(P<0.005,P<0.0001).But there was no significant difference in the levels of CRP between SAP group and NCHD group. Conclusion Acute myocardial infarction and unstable angina pectoris are both acute coronary artery syndromes.The results suggested that acute coronary artery syndromes is correlated with acute inflammation.