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Depressed levels of circulating menaquinones in patients with osteoporotic fractures of the spine and femoral neck |
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| Authors: | SJ Hodges MJ Pilkington TCB Stamp A Catterall MJ Shearer L Bitensky J Chayen |
| Institution: | a Unit of Cellular Pharmacology and Toxicology, Robens Institute, University of Surrey, Guildford, Surrey, GU2 5XH, U.K. b Royal National Orthopaedic Hospital, London, U.K. c Charing Cross Hospital, London, U.K. d Department of Haematology, Guy's Hospital, London, U.K. |
| Abstract: | Vitamin K1 functions in the conversion of glutamate residues, present in certain bone peptides, into the putatively active γ-carboxyglutamate form. We have shown previously that the circulating levels of vitamin K1 are depressed in osteoporotic patients. However, it is known that menaquinones (vitamin K2:MK) may be more effective than vitamin K1 in this conversion of the inactive to active form of glutamate residues. A procedure for measuring such menaquinones has now demonstrated a marked deficiency of MK-7 and MK-8 in patients with osteoporotic fractures. It is suggested that estimates of circulating levels of K1, MK-7, and MK-8 might provide a biochemical risk marker of osteoporotic fractures. |
| Keywords: | Electrochemistry High performance liquid chromatography Menaquinones Osteoporosis Vitamin K |
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