循经点穴对甲氨蝶呤治疗类风湿关节炎的增效减毒作用

目的：观察循经点穴对甲氨蝶呤治疗类风湿关节炎的增效减毒作用.方法：选取64例使用甲氨蝶呤治疗的类风湿关节炎患者,采取随机的方法分为治疗组和对照组各32例,对照组采用甲氨蝶呤联合硫酸羟氯喹方案,并服用叶酸片;治疗组采用甲氨蝶呤联合硫酸羟氯喹方案,并循经点按脾经、胃经、肝经、胆经,两组治疗1年后观察治疗结果.结果：在增效方面,治疗组明显进步23例,进步7例,改善1例,无效1例,总有效率为96.88%（95%CI=83.68%～99.90%）;对照组明显进步10例,进步11例,改善5例,无效6例,总有效率为81.25%（95%CI=67.73%～94.52%）;两组综合疗效比较（u=3.1939,P=0.0022）,差异有显著性意义;在减毒方面,治疗组与对照组比较,致肝损害、胃肠道反应等毒副作用更小（P〈0.05）.结论：循经点穴对甲氨蝶呤治疗类风湿关节炎有明显的增效减毒作用,其收益为OR=0.14（95%CI=0.02～1.24）.NNT=6（95%CI=3.2～298.5）.

Synergia and Attenuation of Attacking a Vital Point Following Meridian on Rheumatoid Arthritis from Methopterin

Objective： To observe the efficacy of synergia and attenuation of attacking a vital point following meridian on rheumatoid arthritis. Method： 64 cases with rheumatoid arthritis treated with methopterin were divided into two groups randomly,32 cases in each group. Treatment group was treated with methopterin and hydroxychloroquine sulfate combined with attacking a vital point following spleen meridian, stomach meridian, liver meridian and gallbladder meridian, and control group was done with methopterin and hydroxychloroquine sulfate combined with Acidum Folicum Tablet. After I year of treatment the therapeutic result was recorded. Result： About synergia in treatment group 23 cases were recovered ,7 ones excellent, 1 ones effective, and 1 one ineffective. The total effective rate was 96. 88% （95% CI =83.68% -99.90% ）. In control group 10 cases were recovered,ll ones excellent,5 ones effective, and 6 ones ineffective. The total effective rate was 81.25% （95% CI = 67.73% -94. 52% ）. There was significant difference between the two groups （ u = 3. 193 9, P = 0. 002 2）. And about attenuation treatment group had less side effect of hepatic lesion and less gastrointestinal tract complaint than control group （P 〈 0. 05 ）. Conclusion： Attacking a vital point following meridian has good efficacy of synergia and attenuation on rheumatoid arthritis caused by methopterin ,OR =0. 14 （95% CI =0. 02 - 1.24） ,NNT =6 （95% CI =3.2 -298.5）.