Association between bone mineral density and lumbar disc degeneration |
| |
| Affiliation: | 1. Bone and Cartilage Research Unit, Surgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland;2. Department of Orthopedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland;3. Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland;4. Department of Radiology, Kuopio University Hospital, Kuopio, Finland;5. Lapland Hospital District, Rovaniemi, Finland;6. Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland;1. Department of Medicine, School of Medicine and Public Health, University of Wisconsin Osteoporosis Clinical Research Program, Madison, WI, USA;2. MRC Lifecourse Epidemiology Unit, University of Southampton, United Kingdom;3. NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom;4. NIHR Nutrition Biomedical Research Centre, Southampton General Hospital, University of Southampton and University Hospital Southampton NHS Trust, Southampton, United Kingdom;1. Northern Ireland Regional Medical Physics Agency, Royal Group of Hospitals, Belfast, Northern Ireland;2. Centre for Experimental Medicine, Queens University Belfast, School of Medicine, Dentistry and Biomedical Sciences Institute of Clinical Science—Block A, Royal Group of Hospitals, Belfast, Northern Ireland;1. Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada;2. Department of Medicine, McGill University, Montreal, QC, Canada;3. Department of Medicine, Memorial University, St. John''s, NL, Canada;4. Department of Medicine, University British Columbia, Vancouver, BC, Canada;5. Department of Medicine, University of Toronto, Toronto, ON, Canada;6. Department of Medicine, University of Saskatchewan, Saskatoon, SK, Canada;7. Department of Medicine, Queen''s University, Kingston, ON, Canada;8. Departments of Medicine, Oncology, and Community Health Sciences, University of Calgary, Calgary, AB, Canada;9. Division of Endocrinology and Metabolism, Dalhousie University, Halifax, NS, Canada;10. Department of Radiology, University British Columbia, Vancouver, BC, Canada;11. Cancer Care Ontario, Toronto, ON, Canada;1. Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina;3. Section of Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina;2. Department of Epidemiology, Galling''s School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina |
| |
| Abstract: | ![]()
ObjectivesHigher vertebral bone mineral density (BMD) has been found to be related with lumbar disc degeneration (LDD), while relationship between femoral neck BMD and LDD remains controversial. The aim of our research was to study the relationship between LDD and BMD of the lumbar spine and femoral neck.Study designThe study population consisted of 168 postmenopausal women (aged 63.3–75.0 years, mean 68.6 years) from the prospective OSTPRE and OSTPRE-FPS study cohorts. The severity of LDD was graded from T2-weighted MRI images using the five-grade Pfirrmann classification. Four vertebral levels (L1-L4) were studied (total 672 discs). The association between lumbar BMD and Z-score and the severity of LDD was studied separately for each vertebral level with AN(C)OVA analysis, using potential confounders as covariates.ResultsHigher lumbar BMD and Z-score were associated with more severe LDD at all studied levels (L1-L4): between L4-L5 disc and L4 BMD (p = 0.044) and L4 Z-score (p = 0.052), between L2-L3 disc and L3 BMD (p = 0.001) and at all other levels (p < 0.001). The mean degeneration grade of the studied discs was associated with the mean L1-L4 BMD and Z-score (p < 0.001). Statistical significance of any result did not alter after controlling for confounding factors. There was no significant association between femoral neck BMD and LDD.ConclusionsHigher lumbar BMD/Z-score were associated with more severe LDD. There was no significant association between femoral neck BMD and disc degeneration. Femoral neck BMD may be a more reliable measurement for diagnosing osteoporosis in postmenopausal women with degenerative changes in the lumbar spine. |
| |
| Keywords: | Bone mineral density Intervertebral disc degeneration Postmenopausal women Lumbar spine Osteoporosis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
