| 穹窿体与肿瘤多药耐药 |
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| 引用本文： | 谢福权,崔德威. 穹窿体与肿瘤多药耐药[J]. 医学综述, 2008, 14(9): 1326-1328 |
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| 作者姓名： | 谢福权 崔德威 |
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| 作者单位： | 广东医学院附属医院耳鼻咽喉头颈外科,广东,湛江,524000 |
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| 摘 要： | 穹窿体是真核细胞中的核糖核蛋白颗粒,由肺耐药蛋白、穹窿体多聚腺苷二磷酸聚合酶、端粒酶相关蛋白和穹窿体RNA构成,其主要成分为肺耐药蛋白。肺耐药蛋白是介导肿瘤多药耐药的蛋白之一,可能与肿瘤的治疗效果和临床预后相关。穹窿体可能通过介导药物转运或者信号转导引起肿瘤的多药耐药。文章介绍了穹窿体的结构、成分及其介导多药耐药机制研究的新进展。
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| 关 键 词： | 穹窿体 肺耐药蛋白 多药耐药 |
| 文章编号： | 1006-2084(2008)09-1326-03 |
| 修稿时间： | 2007-08-29 |
Vault and Tumor Multidrug Resistance |
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| XIE Fu-quan,CUI De-wei. Vault and Tumor Multidrug Resistance[J]. Medical Recapitulate, 2008, 14(9): 1326-1328 |
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| Authors: | XIE Fu-quan CUI De-wei |
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| Affiliation: | XIE Fu-quan,CUI De-wei.(Department of Otolaryngology-Head , Neck Surgery,the Affiliated Hospital of Guangdong Medical College,Zhanjiang 524000,China) |
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| Abstract: | Vaults are large ribonucleoprotein particles found in eukaryotic cells.Each vault particle is composed of 96 lung resistance protein molecules,8 molecules of vault poly(ADP-ribose)polymerase,2 molecules of telomerase-associated protein 1,and at least 6 molecules of vault RNA.The major component of vaults is lung resistance proteins mediating multidrug resistance.Lung resistance proteins may be associated with the therapeutic efficacy and prognosis of tumor.Vaults probably play a role as transport vehicles o... |
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| Keywords: | Vault Lung resistance protein Multidrug resistance |
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