脑梗死患者血清C反应蛋白检测的临床意义

目的探讨急性脑梗死患者血清C反应蛋白（CPR）浓度变化及对其预后的影响。方法对85例脑梗死，毫者、26例腔隙性脑梗死患者和30名健康体检者（对照组）进行血清CPR含量检测，计算异常率，并按照脑梗死患者临床神经功能缺损程度评分（CNFDS）标准进行评分。结果脑梗死组CRP含量高于腔隙性脑梗死组，腔隙性脑梗死组高于对照组（P均〈0．05）。脑梗死组CRP异常率高于腔隙性脑梗死组。CRP异常的患者CNFDS评分的改善低于CRP正常组，且CRP异常者预后中无变化和死亡率明显高于正常对照组。结论CRP水平是反映脑梗死预后的一个重要标志物。

Clinical significance of serum C-reactive protein in patients with cerebral infarction

Objective To investigate the serum level of C-reative protein(CRP) in patients with cerebral infarction and its effect on the prognposis of brain infarction.Methods 111 patients(85 with thrombosis and 26 with lacunar infarction) and 30 healthy persons as control were enrolled in this study.The serum level and abnormal rate of CRP were determined.All the patients were scored by clinic neurological function deficit scale(CNFDS).Results The serum level of CRP in the patients with thrombosis was higher than that in patients with lacunar infarction.It was also higher in the patients with lacunar infarction(P<0.01).Higher abnormal rate of CRP was found in the patients with thrombosis than in the patients with lacunar infarction(P<0.05).The gronp with abnormal serum level of CRP had lower score of CNFDS and worse prognosis(all P<0.05).Conclusion Serum level of CRP is an important prognosic marker for cerebral infarction.