Retention of maze performance inversely correlates with N-methyl-D-aspartate receptor number in hippocampus and frontal neocortex in the rat |
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| Authors: | G L Wenk C M Grey D K Ingram E L Spangler D S Olton |
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| Affiliation: | Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218. |
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| Abstract: | ![]()
The N-methyl-D-aspartate (NMDA) receptor may play a critical role in learning and memory. In the present study, a significant correlation was found between the number of NMDA-displaceable, Na+-independent L-[3H]glutamate binding sites in the hippocampus and neocortex of young rats and the mean number of errors during retention, but not acquisition, in a 14-unit T-maze. |
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