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The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4 T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs |
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| Authors: | Susanna Commandeur Susan J.F. van den Eeden Karin Dijkman Simon O. Clark Krista E. van Meijgaarden Louis Wilson Kees L.M.C. Franken Ann Williams Dennis Christensen Tom H.M. Ottenhoff Annemieke Geluk |
| Affiliation: | 1. Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands;2. Statens Serum Institut, Copenhagen, Denmark;3. Public Health England, Microbiology Services, Porton Down, Salisbury, Wiltshire, United Kingdom |
| Abstract: | Tuberculosis (TB) remains a life-threatening infectious disease of global proportions with serious negative health and economic consequences. The lack of sufficient protection induced by Mycobacterium bovis BCG, the current vaccine for TB, as well as the impact of HIV co-infection and the emergence of drug resistant Mycobacterium tuberculosis (Mtb) strains all urge for improved vaccines against TB. |
| Keywords: | HLA-DR3 Infection-specific IVE-TB antigen Mtb Rv2034 TB vaccine |
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