| 人神经胶质祖细胞移植于小鼠脑内两侧侧脑室周区后发育成人星形胶质细胞 |
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| 引用本文： | 韩笑宁,禹红梅,方秀斌. 人神经胶质祖细胞移植于小鼠脑内两侧侧脑室周区后发育成人星形胶质细胞[J]. 解剖科学进展, 2011, 17(2): 164-167 |
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| 作者姓名： | 韩笑宁 禹红梅 方秀斌 |
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| 作者单位： | 1. 中国医科大学,神经生物学教研室,辽宁,沈阳,110004
2. 中国医科大学,附属第一医院精神内科,辽宁,沈阳,110004 |
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| 摘 要： | 目的观察人神经胶质祖细胞移植于小鼠脑内两侧侧脑室周区后的形态结构发育变化。方法将人神经胶质祖细胞移植入出生1天的小鼠脑内两侧侧脑室周区,用免疫荧光组化技术和共聚焦显微镜观察移植6个月后,小鼠脑内人神经胶质祖细胞的分布、分化和形态结构的特点。结果人神经胶质祖细胞移植6个月后成功地在小鼠脑内存活并广泛分布,主要发育成人神经胶质酸性蛋白(glial fibrillary acidic protein GFAP)阳性的星形胶质细胞,表现人星形胶质细胞的形态结构特点,部分神经胶质祖细胞分化成硫酸软骨素蛋白多糖(chondroitin sulphate proteoglycan,NG2)阳性的细胞。结论人神经胶质祖细胞移植小鼠脑内环境中主要分化为GFAP阳性的星形胶质细胞和部分NG2阳性细胞。
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| 关 键 词： | 人神经胶质祖细胞 星形胶质细胞 小鼠 |
Differentiation of human glia progenitor cells into astrocytes after their transplantation into bilateral periarea of lateral ventricles of mouse brain |
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| HAN Xiao-ning,YU Hong-mei,FANG Xiu-bin. Differentiation of human glia progenitor cells into astrocytes after their transplantation into bilateral periarea of lateral ventricles of mouse brain[J]. Progress of Anatomical Sciences, 2011, 17(2): 164-167 |
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| Authors: | HAN Xiao-ning YU Hong-mei FANG Xiu-bin |
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| Affiliation: | HAN Xiao-ning1,YU Hong-mei2,FANG Xiu-bin1(1. Department of Neurobiology,2. Department of Neurology of the First Affiliated Hospital,China Medical University,Liaoning Shenyang 110004 China) |
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| Abstract: | Objective To observe the mophological development and differentiation of human gila progenitor cells after their transplantation into bilateral periarea of the lateral ventricles of mouse brain. Method Human glia progenitor cells were transplanted into bilateral periarea of the lateral ventricles of mouse brain at first postnatal day(PND1) ,6 months after transplantation,the distribution,differentiation and mophological features of the human cells were observed by immuno fluorescence staining and confocal m... |
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| Keywords: | glia progenitor cells astrocytes mouse |
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