低分子肝素钙联合丹参对早发型重度子痫前期围产结局的影响

目的:观察低分子肝素钙+丹参治疗早发型重度子痫前期对围产结局的影响。方法:选取孕龄26～34周重度子痫前期患者116例,自愿分为A组32例(硫酸镁常规治疗),B组28例(硫酸镁+低分子肝素钙组),C组30例(硫酸镁+丹参组),D组26例(硫酸镁+低分子肝素钙+丹参组)。对比4组在延长孕龄时间、脐动脉S/D比值、羊水指数、胎盘重量、新生儿体重、Apgar评分的差异。结果:D组延长孕龄时间最长,脐动脉S/D比值下降,羊水量,新生儿体质量均增加,新生儿窒息率下降,与其他3组对比差异有统计学意义,P<0.05;胎盘重量增加,与A组对比差异有统计学意义,P<0.05;与B、C组对比差异无统计学意义,P>0.05。结论:低分子肝素钙联合丹参治疗早发型重度子痫前期,可改善胎盘功能,延长孕龄,明显改善新生儿预后,二者联合应用有协同作用。

The perinatal influence of low molecular heparin calcium combined with salvia miltiorrhiza on early onset severe pre-eclampsia

Objective:To analyze the perinatal effect of low molecular heparin calcium combined with salvia miltiorrhiza on early onset severe pre-eclampsia.Methods:116 patients with early onset severe pre-eclampsia at 26~34 weeks of gestational age were divided into four groups by volunteered,including Group A(32 patients): magnesium sulfate conventional treatment;Group B(28 patients): magnesium sulfate+low molecular heparin calcium;Group C(30 patients): magnesium sulfate+salvia miltiorrhiza;Group D(26 patients): magnesium sulfate+salvia miltiorrhiza+low molecular heparin calcium.Time of prolonged gestational age,umbilical arterial S/D ratio,amniotic fluid index,placenta weight,neonatal weight and Apgar score were measured.Results:The time of prolonged gestational age in group D was the longest.In group D,umbilical arterial S/D ratio was decreased,amniotic fluid index and neonatal weight were increased,the neonatal Apgar score was improved.Compared with the other three groups,there were significant differences(P<0.05).In group D,placenta weight was increased,there was significant difference between group D and group A(P<0.05).Compared with group B and group C,there were no differences(P>0.05).Conclusion:Low molecular heparin calcium combined with salvia miltiorrhiza could improve the function of placenta,prolong gestational age and significantly improve neonatal prognosis of early onset severe pre-eclampsia.The application of low molecular heparin calcium combined salvia miltiorrhiza is more synergy than by single.