| 储存条件对丙戊酸钠血药浓度测定的影响研究 |
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| 引用本文： | 成凤英,黄燕,江晟,常惠礼,夏泉,许杜娟. 储存条件对丙戊酸钠血药浓度测定的影响研究[J]. 安徽医药, 2013, 0(7): 1244-1245 |
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| 作者姓名： | 成凤英 黄燕 江晟 常惠礼 夏泉 许杜娟 |
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| 作者单位： | [1]暨南大学第五附属医院药学部,广东清远511500 [2]安徽医科大学第一附属医院药剂科,安徽合肥230022 |
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| 基金项目： | 安徽省高校省级教学研究重点项目（No 2012jyxm162） |
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| 摘 要： | 目的考察两种储存条件对丙戊酸钠血药浓度测定结果的影响。方法取服用丙戊酸钠患者的全血标本分别在冬季室温(12℃)和冰箱冷藏(4℃)储存,用高效液相色谱法测定0、24、48、72 h时丙戊酸钠血药浓度。结果全血标本在两种储存条件下72 h内,丙戊酸钠的血药浓度无显著性变化(RSD<10%)。结论丙戊酸钠全血标本在室温(12℃)和冰箱冷藏(4℃)储存72 h保持稳定,不影响测定结果。
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| 关 键 词： | 丙戊酸钠 血药浓度 储存条件 |
Effects of storage conditions on the stability of Valproic Acid concentration in blood samples |
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| Affiliation: | CHENG Feng-ying,HUANG Yan,JIANG Sheng,et al(1.Dept.of Pharmacy,The Fifth Affiliated Hospital of Jinan University,Qingyuan,Guangdong 511500,China;2.Dept.of Pharmacy,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China) |
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| Abstract: | Objective To investigate the effects of storage conditions on the stability of Valproic Acid concentration of blood samples.Methods Samples of the patient’s blood were collected and stored at room temperature（12℃） and 4℃ respectively.The stabilities of Valproic Acid concentration in blood were tested by HPLC method at 0,24,48 and 72 h.Results The concentration of Valproic Acid in blood at different environment had no significant difference within 72h（RSD 10%）.Conclusion The concentration of Valproic Acid is stable in blood at room temperature（12℃） and 4℃ within 72 h. |
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| Keywords: | Valproic Acid blood concentration storage conditions |
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