血清淀粉样蛋白A在呼吸系统疾病中的研究进展

血清淀粉样蛋白A(serum amyloid A,SAA)是一个非常敏感的急性时相蛋白.研究发现SAA与C-反应蛋白相比,其灵敏度、特异度更高,尤其病毒感染时其血清水平显著升高,而C-反应蛋白血清水平基本正常或轻度升高.其研究涉及呼吸系统多种疾病,如:上呼吸道感染、急性气管-支气管炎、肺炎、慢性阻塞性肺疾病、肺癌、过敏性鼻炎和支气管哮喘、肺结核、肺囊性纤维化、肺结节病;此外在淀粉样变性、自身免疫性疾病,移植及心血管疾病中也有广泛研究.

Research advances of serum amyloid A in respiratory systemic diseases

Serum amyloid A(SAA) is an extremely sensitive acute phase protein. Reasearch found that SAA is higher than C-reactive protein(CRP) in sensitivity and specificity. SAA is strikingly elevated especially when body is infected by virus, however,CRP is basically normal or a little higher. SAA is studied in lots of respiratory systemic diseases, such as: upper respiratory tract infections, acute tracheobronchitis, pneumonia, chronic obstructive pulmonary disease, pulmonary carcinoma, allergic rhinitis and bronchial asthma,pulmonary tuberculosis, cystic fibrosis, pulmonary sarcoidosis; SAA is also extensively studied in amyloidosis,autoimmune diseases, transplantation and cardiovascular diseases.