| 皮肤鳞状细胞癌组织中HB-EGF的表达意义 |
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| 引用本文： | 郑焱,彭振辉,谭升顺,郗彦萍,王一理. 皮肤鳞状细胞癌组织中HB-EGF的表达意义[J]. 医学争鸣, 2003, 24(4): 366-368 |
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| 作者姓名： | 郑焱 彭振辉 谭升顺 郗彦萍 王一理 |
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| 作者单位： | 1. 西安交通大学第二医院皮肤科,陕西,西安,710004
2. 西安交通大学基础医学院免疫病理研究所,陕西,西安,710061 |
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| 基金项目： | 国家自然科学基金资助项目 (30 0 70 699) |
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| 摘 要： | 目的：探讨肝素结合表皮生长因子样生长因子（HB－EGF）在皮肤鳞状细胞癌中的作用机制。方法：用原位杂交的方法检测正常组织；癌旁组织和鳞状细胞癌皮损组织中HB－EGF mRNA的表达。结果：在正常皮肤组织中，HB－EGF表达于基底层（100．0％），基底上层仅有少量表达（12．5％）；在癌旁组织中，HB－EGF不仅位于基底层（100．0％），且在基底上层也有表达（91．7％）；在鳞状细胞癌皮损中，全层几乎无HB－EGF的表达（8．3％）。结论：HB－EGF在鳞状细胞癌发病的早期阶段起关键作用，基底层中的HB－EGF对保持这表皮形态有重要作用。
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| 关 键 词： | 皮肤鳞状细胞癌 HB－EGF 皮肤肿瘤 原位杂交 肝素 |
| 文章编号： | 1000-2790(2003)04-0366-03 |
| 修稿时间： | 2002-06-06 |
Expression and significance of HB-EGF in skin squamous cell carcinoma |
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| Abstract: | AIM: To investigate the pathogenesis of HB EGF in skin squamous cell carcinoma. METHODS: HB EGF mRNA in normal tissues, tissues adjacent to cancer and skin squamous cell carcinoma lesions were detected by hybridization in situ . RESULTS: In normal skin tissues, the stain of HB EGF was located in the basal layer of epidermis (100 0%) and only little expression in superabasal layers (12 5%). In tissues adjacent to cancer, there was expression not only in the basal layer (100 0%) but also in superabasal layers (91 7%), while in squamous cell carcinoma, there was nearly no expression (8 3%).CONCLUSION: HB EGF may play an important role in the early pathogenesis of skin squamous cell carcinoma and play the role of maintaining the phenotype of normal skin tissues in basal layer. |
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| Keywords: | heparin epidermal growth factor urogastrone skin neoplasms carcinoma squamous cell in situ hybridization |
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