细胞毒素相关基因A及细胞毒素相关蛋白A研究进展

细胞毒素相关基因A及细胞毒素相关蛋白A是幽门螺杆菌重要的毒力因子,具有遗传基因多态性和地区分布的差异,与消化道溃疡、胃炎、胃癌及一些非胃肠道疾病的发生发展密切相关,并影响胃损害的严重程度及最终临床结局。其致病机制主要与影响多条细胞信息传递通路有关。

Research Progress of Cytotoxin Associated Gene A and Cytotoxin Associated Protein A

Cytotoxin associated gene and cytotoxin associated protein A are important virulence factors of Helicobacter pylori.These virulence factors have the genetic polymorphism and differences in regional distribution,and they are closely related to gastrointestinal ulcers,gastritis,gastric cancer and some non-gastrointestinal diseases.They also affected the severity of gastric damage and the ultimate clinical outcome.Its pathogenesis is mainly related with mechanisms,such as multiple access information transmissi...