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神经妥乐平对周围神经损伤的治疗作用
引用本文:胡昔权,窦祖林,朱洪翔. 神经妥乐平对周围神经损伤的治疗作用[J]. 中国新药与临床杂志, 2003, 22(2): 94-96
作者姓名:胡昔权  窦祖林  朱洪翔
作者单位:中山大学附属第三医院,康复科,广东,广州,510630
摘    要:
目的 :观察神经妥乐平对周围神经损伤病人的疗效。方法 :86例周围神经损伤病人在常规治疗基础上随机分为神经妥乐平治疗组 44例 ,给神经妥乐平wk 1~ 2 ,6mL ,iv,qd或 3mL ,im ,qd ,wk3~4改为口服 ,2片 ,bid ;对照组 42例仅进行常规治疗。治疗前后观察疼痛、麻木、感觉减退、感觉过敏、乏力等指标的改善情况。结果 :神经妥乐平组的改善率分别为 87% (疼痛 )、88% (乏力 )、88% (感觉减退 )、62 % (麻木 )、5 6% (感觉过敏 )。疼痛与乏力和对照组相比 ,差异有显著意义 (P <0 .0 5 )。神经妥乐平组总有效率在治疗 4wk时为 1 0 0 % ,对照组为 69% ,2组间比较经Ridit分析差异有非常显著意义 (P <0 .0 1 )。结论 :神经妥乐平可安全、有效治疗周围神经损伤

关 键 词:周围神经疾病  损伤严重程度评分  神经妥乐平  药物疗法  牛痘苗
文章编号:1007-7669(2003)02-0094-03

Treatment effect of neurotropin on peripheral nerve injury
HU Xi quan,DOU Zu lin,ZHU Hong xiang. Treatment effect of neurotropin on peripheral nerve injury[J]. Chinese Journal of New Drugs and Clinical Remedies, 2003, 22(2): 94-96
Authors:HU Xi quan  DOU Zu lin  ZHU Hong xiang
Abstract:
AIM: To observe the efficacy of neurotropin in the treatment of preipheral nerve injury.METHODS: Eighty six patients with preipheral nerve injury who accepted conventional therapy were randomly divided into two groups. Forty four patients M 26, F18; age (53 ± s 6) a, were treated with neurotropin (6 mL, iv,qd or 3mL, im, qd for 2 wk; then two tablets, po , bid for another 2 wk as a course).The other forty two patients, M 27,F15; age (55±5) a, as control group accepted conventional therapy only. Before and after treatment, symptoms and signs of neuropathy including spontaneous pain, numbness, hypoesthesia, hyperesthesia, weakness, etc.were examined for all patients. RESULTS: After treatment for 4 wk, the improvement rate of neurotropin group was 87 % for spontaneous pain, 88 % for weakness, 88 % for hypoesthesia, 62 % for numbness and 56 % for hyperesthesia. There was a significant difference for spontaneous pain and weakness between neurotropin group and the control group, ( P <0.05). On the wk 4, the total efficacy rate of neurotropin group was 100%, and that of the control group was 69 %. There was a greatly significant difference between two groups ( P < 0.01) . CONCLUSION:Neurotropin is safe and effective in treating peripheral nerve injury.
Keywords:peripheral nerve diseases  injury severity score  neurotropin  drug therapy  smallpox vaccine
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