2型糖尿病患者糖尿病视网膜病变危险因素分析

目的分析2型糖尿病患者糖尿病视网膜病变(DR)相关危险因素。方法2型糖尿病患者141例,根据有无糖尿病视网膜病变及病变程度分为3组:正常视网膜(NDR)组、非增殖型视网膜病变(NPDR)组和增殖型视网膜病变(PDR)组进行临床分析。结果①3组间体重指数(BMI)、空腹血糖(FPG)、2h血糖(2hPG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)和高密度脂蛋白胆固醇(HDL)差异无统计学意义;3组间年龄、病程、收缩压(SBP)、舒张压(DBP)、胆固醇(CHO)、低密度脂蛋白胆固醇(LDL)、24h尿蛋白排泄量和血肌酐(SCr)差异有统计学意义。②NPDR、PDR组年龄、病程、SBP、CHO、LDL和24h尿蛋白排泄量较NDR组明显升高(P<0.05)。③多元回归分析表明:病程、SBP、24h尿蛋白排泄量和血胆固醇是DR发生的独立危险因素。结论血糖、血压、血脂控制不良和尿蛋白排泄增加是导致DR进展的重要因素,早期常规眼底检查和积极干预治疗非常重要。

Analysis of the correlated risk factors of retinopathy in type 2 diabetics

Objective To analysis the correlated risk factors of retinopathy in type 2 diabetics. Methods 141 cases with type 2 diabetes mellitus were divided into three groups: no retinopathy group(NDR), nonproliferative retinopathy group((NPDR) and proliferative retinopathy group((PDR) to analysis its correlated risk factors.Results ①Body mass index (BMI), fasting plasma glucose(FPG), 2 h plasma glucose (2 h PG), HbA1c, triglyceride(TG), HDL were not of significant difference among three groups; Age, course of disease, systolic blood pressure(SBP), diastolic blood pressure (DBP), cholesterol (CHO), LDL, 24 hour urinary protein excretion and serum creatinine(SCr) were significant different among three groups; ②The age, course of disease, systolic blood pressure(SBP), cholesterol(CHO), LDL ,24 hour urinary protein excretion of the NPDR group and PDR group were significantly higher than those of the NDR group(P﹤0.05);③Multiple regression analysis revealed that the four variance, such as course of disease, SBP, 24 hour urinary protein excretion, CHO were the risk factors of DR.Conclusion Poor control of blood glucose, blood pressure , blood lipid(hyper-CHO) and increased urinary protein excretion can result in progression of DR. It is very important to screen for DR and intervention in early phase.