丹参注射液加强缺血预处理对大鼠心肌的保护作用

以整体麻醉SD大鼠心脏冠状动脉左前降支结扎／松开作为缺血／再灌注动物模型，研究丹参注射液（SM）在加强缺血须处理（IP）的心肌保护中的作用。结果显示，IP能减轻复灌性心律失常的严重程度，缩小心肌梗死范围；SM能缩小心肌梗死范围；SM联合IP与单纯IP比较，心肌梗死范围进一步缩小；SM联合IP与单纯SM比较，心律失常严重程度减弱且心肌梗死面积进一步减小。结果表明，SM能加强IP的心肌保护作用，特别是加强IP的抗心肌梗死作用。

Injection Preparation of Dan-shen (Salvia miltiorrhiza) Enhances the Cardioprotective Effects of Ischemic Preconditioning in Rat

The role of injectio Salvia miltiorrhiza (SM) on enhancing the cardioprotective effects of ischemic preconditioning (IP) in anaesthetized rat was investigated. Results showed that IP reduced the severity of reperfusion-induced arrhythmia and limited the infarct size. SM limited the infarct size;SM IP significantly reduced the infarct size as compared with IP alone;and significantly decreased both the infarct size and the severity of reperfusion-induced arrhythmia as compared with SM alone. These results suggested that SM can enhance the cardioprotective effects of IP.