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| 柴胡注射液对小鼠灌流肝脏缺氧复氧损伤的保护作用 | |
| 引用本文： | 汤兵 吴逸人. 柴胡注射液对小鼠灌流肝脏缺氧复氧损伤的保护作用[J]. 医学教育探索, 1998, 0(12): 814-817 |
| 作者姓名： | 汤兵 吴逸人 |
| 作者单位： | 重庆医科大学卫生毒理学教研室!400016(汤兵)，重庆医科大学劳动卫生教研室!400016(吴逸人)，重庆医科大学医学检验系临床生化教研室!400016(康格非) |
| 摘 要： | 采用小鼠离体肝灌流术在Krebs－Henseleit（K－H）灌流液中加入柴胡注射液，观察柴胡对肝缺氧（1h）复氧（1h）的影响。结果表明：柴胡组与缺氧组相比，光镜电镜下肝组织损伤较轻，且肝组织乳酸脱氢酶（LDH）漏出量显著减少，脏／体比、还原型谷胱甘肽（GSH）及黄嘌呤氧化酶（XOD）含量有显著性差异，丙二醇（MDA）生成延迟。揭示柴胡对小鼠离体灌流肝缺氧复氧损伤有明显拮抗作用，其机制与抑制氧自由基形成有关。 |
| 关 键 词： | 柴胡 氧自由基 缺氧复氧 损伤 |
Protective Effect of Chaihu Injection on Hypoxia-reoxygenation-induced Mouse Liver Injury |
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| Tang Bing,Wu Yiren and Kang Gefei. Protective Effect of Chaihu Injection on Hypoxia-reoxygenation-induced Mouse Liver Injury[J]. Researches in Medical Education, 1998, 0(12): 814-817 | |
| Authors: | Tang Bing Wu Yiren Kang Gefei |
| Abstract: | By using isolated mouse liver perfusion model, the protective effect of Chaihu injection on hypoxia-reoxygenation liver injury was studied. The activity of lactate dehydrogenase (LDH) in perfusion liquid, the activity of xanthine oxidase (XOD), the content of glutathione (GSH) and malondialdehyde (MDA) in liver homogenate were investigated at different time courses. Liver pathology by light microscopy and electronic microscopy were observed after perfusion. The result implied that Chaihu injection has a significant protective effect on mouse liver injury induced by hypoxia-reoxygenation perfusion. The mechanism of action may be related to its inhibitory effect on the formation of free radicals. |
| Keywords: | Chaihu injection oxygen free radicals hypoxia-reoxygenation injury |
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