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Synthesis and biological properties of 2-(4-chlorophenyl)-3-morpholin-4-yl-(4-alkoxyphenyl)alkanol hydrochlorides |
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| Authors: | O. A. Papoyan N. K. Gasparyan R. G. Paronikyan A. A. Tatevosyan D. A. Avakimyan G. A. Panosyan G. A. Gevorgyan |
| Affiliation: | 1.Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry,National Academy of Sciences of Armenia,Yerevan,Armenia;2.Molecular Structure Research Center, National Academy of Sciences of Armenia,Yerevan,Armenia |
| Abstract: | New 2-(4-chlorophenyl)-3-morpholin-4-yl-1-(4-alkoxyphenyl)propan-1-ones were synthesized via aminomethylation of 2-(4-chlorophenyl)-1-(4-alkoxyphenyl)ethanones. Reduction of the former by lithium aluminum hydride produced 2-(4-chlorophenyl)-3-morpholin-4-yl-1-(4-alkoxyphenyl)propan-1-ols. Reaction of them with Grignard reagents gave 2-(4-chlorophenyl)-1-morpholin-4-yl-3-(4-alkoxyphenyl)alkan-3-ols. The synthesized compounds exhibited pronounced anticonvulsive and some peripheral n-cholinolytic activities while showing no antibacterial activity. |
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