| 环氧化酶-2基因多态性与肿瘤遗传易感性研究进展 |
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| 引用本文： | 高婷花,钱晓萍,刘宝瑞. 环氧化酶-2基因多态性与肿瘤遗传易感性研究进展[J]. 陕西肿瘤医学, 2011, 0(2): 364-367 |
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| 作者姓名： | 高婷花 钱晓萍 刘宝瑞 |
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| 作者单位： | [1]东南大学医学院,江苏南京210008 [2]南京大学医学院附属鼓楼医院肿瘤中心,江苏南京210008 |
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| 基金项目： | 【基金项目】江苏省南京市科技局国际联合研发项目（编号：201001138） |
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| 摘 要： | 环氧化酶-2（cyclooxygenase-2,COX-2）是前列腺素（prostaglandins,PGs）合成过程中的关键限速酶之一,可将花生四烯酸代谢成各种PGs产物,从而维持机体的病理生理过程,参与炎症反应,疼痛反应,与肿瘤的发生、发展密切相关。因此,COX-2基因成为近年来研究的热点。最近国内外众多关于COX-2基因多态性与肿瘤易感性相关的病例对照研究,均表明COX-2单核苷酸多态性与多个肿瘤的易感性相关。这对肿瘤的个体化治疗有一定的指导作用。
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| 关 键 词： | COX-2 基因多态性 遗传易感性 肿瘤 |
The study of COX -2 genetic polymorphisms and tumor hereditary susceptibilily |
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| Affiliation: | GAO Ting - hua, QIAN Xiao - ping, LIU Bao ,- rui( 1 Medical College of Southeast University, Nanjing 210009, China ;2 Department of Oncology, Drum Tower Hospital Affiliated to Medical School of Nanjing University , Nanjing 210008, China. ) |
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| Abstract: | Cyclooxygenase -2 （COX -2） is one of the key rate -limiting enzymes in the conversion of arachidonic acid to prostaglandins （PGs） ,which participates in pathophysiological processes like inflammation,pain and also ap- pears to play a role in tumor occurrence and development. Thus, COX - 2 gene becomes the hot spot in current stud- ies. Recently, the most foreign and native case -control researches, with regard to the relation between COX -2 genetic polymorphisms and tumor susceptibility,clue to that there are some relationship between them. That may generate some guidance of individual treatment of cancer. |
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| Keywords: | COX - 2 genetic polymorphisms susceptibility tumor |
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