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低分子肝素联合化疗治疗晚期乳腺癌
引用本文:赵丽丽,刘力新,张秀娟. 低分子肝素联合化疗治疗晚期乳腺癌[J]. 陕西肿瘤医学, 2011, 0(12): 2444-2446
作者姓名:赵丽丽  刘力新  张秀娟
作者单位:山东省巨野县人民医院肿瘤内科,山东巨野274900
摘    要:目的:观察低分子肝素联合化疗对晚期乳腺癌的疗效及对血栓标志物(D二聚体、纤维蛋白原)的影响。方法:42例晚期乳腺癌患者随机分成两组。A组:TP化疗组,应用紫杉醇135mg/m2第1天静脉滴注,顺铂70 mg/m2第2天静脉滴注。B组:低分子肝素联合TP方案化疗组,在A组用药的基础上加用低分子肝素5000U皮下注射12小时1次,共用5天。结果:低分子肝素组D二聚体化疗前后无明显变化(P〉0.05),纤维蛋白原化疗后明显低于化疗前水平(P〈0.05)。近期疗效肝素组(52.4%)高于对照组(42.8%),但统计学差异无显著性(P〉0.05)。低分子肝素组治疗的不良反应较单纯化疗组统计学差异无显著性(P〉0.05)。结论:应用低分子肝素联合化疗能改善晚期乳腺癌高凝状态,无明显不良反应。

关 键 词:低分子肝素  化疗  晚期乳腺癌

Low molecular heparin combined chemotherapy in advanced breast cancer
ZHAO Lili,LIU Lixin,ZHANG Xiujuan. Low molecular heparin combined chemotherapy in advanced breast cancer[J]. Shaanxi Oncology Medicine, 2011, 0(12): 2444-2446
Authors:ZHAO Lili  LIU Lixin  ZHANG Xiujuan
Affiliation:(Department of Tumor,Juye County People's Hospital,Shandong Juye 274900,China )
Abstract:Objective:To observe the effect of low molecular heparin in combined with chemotherapy on blood clots markers D dimmers and fibrinogen in advanced breast cancer.Methods: Total of 42 patients with metastatic breast cancer were randomly divided into two groups,patients in group A received paclitaxel plus cisplatin;patients in group B received regimen TP combined with low molecular heparin 5000U subcutaneously injected q12 hours per day,for 5 days.Group B: low molecular heparin and TP scheme chemotherapy group,on the base of drug in group A combined with low molecular heparin 5000U subcutaneous injection 12 hours 1 times,for five days.Results: There was no significant difference in low molecular heparin group D-dimers before and after chemotherapy.Level of fibrinogen after chemotherapy was significantly lower than the level before chemotherapy(P〈0.05).There was no significant difference in adverse effect between the two groups(P 0.05).There was on significant differences in adverse reactions between 2 groups.Conclusion: The application of low molecular heparin combined chemotherapy can improve high pour-point state in advanced breast cancer without obvious adverse reactions.
Keywords:low molecular heparin  chemotherapy  metastatic breast cancer
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