A family cluster of giardiasis with variable treatment responses: refractory giardiasis in a family after a trip to India |
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| Affiliation: | 1. Barcelona Centre for International Health Research (CRESIB Hospital Clínic-Universitat de Barcelona), Barcelona, Spain;2. Area of Parasitology, Department of Microbiology, Preventive Medicine and Public Health, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain;3. Department of Microbiology, Hospital Clínic, Barcelona, Spain |
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| Abstract: | Persistence of giardiasis after some of the recommended drugs is occurring with increasing frequency. We describe the follow-up of four members of a family with giardiasis through microscopic observation, immunochromatography and PCRs of tpi and β-giardin genes. Three patients did not respond to tinidazole but they were cured after quinacrine. However, PCR became negative at 2 months after negativization of stools in two patients and after 1 year in one patient. In all cases Giardia assemblage B was characterized with high homology between all isolates. Further studies are needed to determine the value of PCR in the diagnosis of Giardia infections. |
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| Keywords: | nitroimidazole polymerase chain reaction quinacrine refractory giardiasis |
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