Molecular epidemiology of OXA-48-producing Klebsiella pneumoniae in France |
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| Affiliation: | 1. Service d''Hygiène Hospitalière, UMR 6249 Chrono-environnement, Centre Hospitalier Régional Universitaire, Université de Franche-Comté, Besançon, France;2. Laboratoire de Bactériologie, CHU Carémeau, Nîmes Cedex 09, France;3. Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier 1, UFR Médecine, Nîmes, France;4. AP-HP, Hôpitaux Universitaires Pitié Salpêtrière – Charles Foix, Bacteriology and Hygiene, Paris, France;5. Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d''Immunologie et des Maladies Infectieuses CIMI, Team E13 (Bacteriology), Paris, France;6. INSERM, U1135, Centre d''Immunologie et des Maladies Infectieuses, CIMI, Team E13 (Bacteriology), Paris, France;7. Service de Microbiologie, Hôpital Beaujon AP-HP, Clichy, France;8. Faculté de Médecine D. Diderot, Paris, France;9. Institut National de la Santé et de la Recherche Médicale, U773, Centre de Recherche Biomédicale Bichat-Beaujon (CRB3), Université Paris 7, Paris, France;10. Service de Bactériologie, CHU Toulouse, Toulouse, France;11. Service de Bactériologie-Hygiène, CHU Tours, Tours, France;12. Service de Bactériologie, CHU Reims, Reims, France;13. Service de Bactériologie, CHU Nancy, Nancy, France;14. Service de Bactériologie, CH Troyes, Troyes, France;15. Service de Bactériologie, CH Antibes, Antibes, France;p. Département DISC, Institut FEMTO-ST, UMR 6174 CNRS, Université de Franche-Comté, Belfort Cedex, France |
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| Abstract: | We characterized 53 OXA-48-producing Klebsiella pneumoniae (OXA-48-Kp) isolated between 2011 and 2013 in 21 French hospitals. All the isolates were genotyped using MLST and PFGE and the population structure of the species was determined by a nucleotide-based analysis of the entire K. pneumoniae MLST database. Most of the OXA-48-Kp isolates also produced CTX-M-15 and remained susceptible to imipenem and meropenem. The isolates were distributed into 20 STs, of which five were dominant (ST15, ST101, ST147, ST395 and ST405). All the OXA-48-Kp clustered in the major clade of K. pneumoniae KpI. |
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| Keywords: | Multidrug resistance multilocus sequence typing phylogenetic analysis |
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