In Vivo Precision of the GE Lunar iDXA for the Assessment of Lumbar Spine,Total Hip,Femoral Neck,and Total Body Bone Mineral Density in Severely Obese Patients |
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| Institution: | 1. Department of Kinesiology and Physical Education, McGill University, Montreal, QC, Canada;2. Bariatric Surgery, McGill University Health Center, Montreal, QC, Canada;1. Department of Family Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan;2. Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK;3. Osteoporosis Treatment Centre, Kuala Lumpur, Malaysia;4. SCBR (Saitama Center for Bone Research), Kubojima Clinic, Saitama, Japan;5. Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia;6. Department of Radiology, Peking Union Medical College Hospital Beijing, Beijing, China;7. Department of Medicine, University of Santo Tomas Hospital, Manila, Philippines;8. Division of Endocrinology, Department of Medicine, National University Health System, Singapore;9. Obstetrician and Gynecologist in Beijing United Family Hospital, Beijing, China;10. Seoul National University College of Medicine, Seoul, Korea;11. Jakarta Osteoporosis Center, Jakarta, Indonesia;12. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;13. Osteoporosis Center, Taiwan Adventist Hospital, Taipei, Taiwan;14. Department of Nuclear Medicine and Radiology, Lin Shin Hospital, Taichung, Taiwan;15. Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan;16. Division of Endocrinology and Metabolism, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan;17. Division of Rheumatology & Allergy, Vanderbilt University Medical Center, Nashville, TN, USA;18. Center of Bone Diseases, Department of Bone & Joint, Lausanne University Hospital, Lausanne, Switzerland;19. WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK;20. Secction of Family Medicine, Department of Internal Medicine, National Cheng Kung University Hospital Dou-Liou Branch, Douliou City, Taiwan;21. Department of Orthopedics, National Taiwan University Hospital, Taipei, Taiwan;1. Osteoporosis Clinical Research Program, University of Wisconsin, Madison, WI, USA;2. Department of Bone and Joint, Center of Bone diseases, Lausanne University Hospital, Lausanne, Switzerland;1. Laboratoire de Physiologie et des Explorations Fonctionnelles, Université de Sousse, Faculté de Médecine Ibn Eljazzar, Sousse, Tunisia;2. Service de Rhumatologie, CHU Farhat Hached, Sousse, Tunisia |
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| Abstract: | No study has evaluated the precision of the GE Lunar iDXATM (GE Healthcare) in measuring bone mineral density (BMD) among severely obese patients. The purpose of the study was to evaluate the precision of the GE Lunar iDXATM for assessing BMD, including the lumbar spine L1–L4, L2–L4, the total hip, femoral neck, and total body in a severely obese population (body mass index BMI] > 40 kg/m2). Sixty-four severely obese participants with a mean age of 46 ± 11 yr, BMI of 49 ± 6 kg/m2, and a mean body mass of 136.8 ± 20.4 kg took part in this investigation. Two consecutive iDXA scans (with repositioning) of the total body (total body BMD TBBMD]), lumbar spine (L1–L4 and L2–L4), total hip (total hip BMD THBMD]), and femoral neck (femoral neck BMD FNBMD]) were conducted for each participant. The coefficient of variation (CV), the root mean square (RMS) averages of standard deviations of repeated measurements, the corresponding 95% least significant change, and intraclass correlations (ICCs) were calculated. In addition, analysis of bias and coefficients of repeatability were calculated. The results showed a high level of precision for total body (TBBMD), lumbar spine (L1–L4), and total hip (THBMD) with values of RMS: 0.013, 0.014, and 0.011 g/cm2; CV: 0.97%, 1.05%, and 0.99%, respectively. Precision error for the femoral neck was 2.34% (RMS: 0.025 g/cm2) but still represented high reproducibility. ICCs in all dual-energy X-ray absorptiometry measurements were 0.99 with FNBMD having the lowest at 0.98. Coefficients of repeatability for THBMD, FNBMD, L1–L4, L2–L4, and TBBMD were 0.0312, 0.0688, 0.0383, 0.0493, and 0.0312 g/cm2, respectively. The Lunar iDXA demonstrated excellent precision for BMD measurements and is the first study to assess reproducibility of the GE Lunar iDXA with severely obese adults. |
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| Keywords: | Bone mineral density iDXA precision repeatability severe obesity |
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