Brainstem auditory electrophysiology is supressed in term neonates with hyperbilirubinemia |
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| Affiliation: | 1. Pediatric Research Centre, University of Tampere, Tampere, Finland;2. Department of Pediatrics, Tampere University Hospital, Tampere, Finland;3. Department of Clinical Neurophysiology, Tampere University Hospital, Tampere, Finland;4. Faculty of Medicine, University of Tampere, Tampere, Finland;5. Pediatric Neurology Unit, Tampere University Hospital, Tampere, Finland;6. Science Center, Pirkanmaa Hospital District, Tampere School of Public Health, University of Tampere, Tampere, Finland;1. University of Strathclyde, Department of Mathematics and Statistics, 26 Richmond Street, Glasgow G1 1XH, United Kingdom;2. Health Protection Scotland, 5 Cadogan Street, Glasgow G2 6QE, United Kingdom;3. International Prevention Research Institute (iPRI), 95 cours Lafayette, 69006 Lyon, France;1. Section of Pediatric Neuroradiology, Division of Pediatric Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, MD, USA;2. Department of Radiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada;3. Kennedy Krieger Institute, Baltimore, MD, USA;4. Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA;5. Department of Diagnostic Imaging, Health Sciences Centre, Winnipeg, Manitoba, Canada;6. Section of Pediatric Neurology, Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada |
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| Abstract: | ![]()
BackgroundWhether hyperbilirubinemia suppresses electrophysiological activity of the neonatal auditory brainstem remains to be investigated.AimTo determine whether hyperbilirubinemia suppresses the brainstem auditory electrophysiology in term neonates.MethodsMaximum length sequence brainstem auditory evoked response (MLS BAER) was recorded shortly after confirming hyperbilirubinemia in 58 term neonates. Wave amplitudes of the response were analyzed in detail.ResultsCompared with age-matched term controls, the neonates with hyperbilirubinemia showed a significant reduction in the amplitudes of MLS BAER waves III and particularly V at all click rates 91–910/s. The reduction tended to be more significant at higher than lower rates. Wave I amplitude was reduced at 910/s. V/I amplitude ratio was decreased at all click rates. Therefore, the amplitudes of MLS BAER, particularly later, waves were all reduced. The amplitudes of all MLS BAER waves tended to be reduced with the increase in total serum bilirubin level. All wave amplitudes were correlated with the level of total serum bilirubin at some or most click rates.ConclusionsBrainstem auditory electrophysiology is suppressed in neonates with hyperbilirubinemia, which related to the severity of hyperbilirubinemia. Wave amplitudes are valuable BAER variables to detect functional impairment of the brainstem and auditory pathway in neonatal hyperbilirubinemia, and are recommended to be used in assessing bilirubin neurotoxicity to the neonatal brain. |
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| Keywords: | Brainstem auditory impairment Evoked potentials Hyperbilirubinemia Neonate Neurological impairment |
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