阿奇霉素与左氧氟沙星门诊治疗慢性支气管炎急性发作的对照研究

目的比较口服阿奇霉素与左氧氟沙星门诊治疗慢性支气管炎轻-中度急性发作的疗效和安全性。方法采用随机、开放、对照方法分为两组,共入选慢性支气管炎轻-中度急性发作门诊就诊者65例,阿奇霉素组32例(实际完成治疗30例),口服阿奇霉素500mg,1次/d,连续5d;左氧氟沙星组33例(实际完成治疗32例),口服左氧氟沙星500mg,1次/d,连续7d。结果治疗后第10天、第24天两组疗效比较差异无统计学意义(P>0.05)。两组临床症状改善所需时间、平均症状严重程度评分比较差异均无统计学意义(P>0.05)。两组细菌清除率、非典型病原体感染率间差异均无统计学意义(P>0.05)。两组不良反应发生率均较低,且差异无统计学意义(P>0.05)。结论口服阿奇霉素5d与口服左氧氟沙星7d门诊治疗慢性支气管炎轻-中度急性加重均有效且安全。

Comparison Study on Acute Exacerbations of Chronic Bronchitis Treated by Azithromycin and Levofloxacin in Outpatients

Objective To compare the safety and efficacy of oral azithromycin and levofloxacin in the treatment of outpatients with mild or medium acute exacerbations of chronic bronchitis(AECB).Methods A randomized,open-label,controlled trial was conducted in sixty-five outpatients who had received a clinical diagnosis of AECB.Thirty two patients were treated with oral azithromycin,500 mg qd for 5 days(acutely 30 patients completed the trial),and 33 patients with oral levofloxacin,500 mg qd for 7 days(acutely 32 patients completed the trial).Results Between the two groups,there was no statistic significance in effect on the10 th days and 24th days after treatment(P>0.05),in both the necessary time for improvement of clinical symptoms and average score of symptom severity(P>0.05),and in bacterial eradication rate and infection rate of non-specific pathogens(P>0.05).The adverse effect rate in both group was lower,with no significant difference(P>0.05).Conclusion A 5-day course of oral azithromycin and a 7-day course of oral levofloxacin are both effective and safe in treatment of outpatients with mild or medium AECB.