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| 普拉克索联合持续正压通气对阻塞性睡眠呼吸暂停低通气综合征合并不宁腿综合征患者睡眠障碍的影响 | |
| 引用本文： | 姜海波,叶小军,阮肇扬,王小川. 普拉克索联合持续正压通气对阻塞性睡眠呼吸暂停低通气综合征合并不宁腿综合征患者睡眠障碍的影响[J]. 中国新药与临床杂志, 2011, 0(10) |
| 作者姓名： | 姜海波 叶小军 阮肇扬 王小川 |
| 作者单位： | 杭州师范大学附属医院神经内科; |
| 摘 要： | 目的观察普拉克索联合持续正压通气(CPAP)对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并不宁腿综合征(RLS)患者睡眠障碍的影响。方法将40例OSAHS合并RLS患者随机分为对照组和观察组,每组20例。对照组在CPAP治疗基础上加用安慰剂,每晚1次;观察组在CPAP治疗基础上加用普拉克索0.125 mg,每晚1次。疗程6 mo。比较2组治疗前后睡眠呼吸紊乱指数(AHI)、周期性腿动指数(PLMI)、腿动指数(LMI)、国际不宁腿量表(IRLS)评分和Epworth嗜睡量表(ESS)评分。结果 2组治疗后各指标均较治疗前有显著下降(P<0.05,P<0.01),治疗后AHI、PLMI、LMI在组间有非常显著差异(均P<0.01)。对照组和观察组IRLS评分(12.00±3.13 vs.7.00±2.13)和ESS评分(3.51±1.28 vs.6.39±1.35)组间比较均有非常显著差异(P<0.01)。结论普拉克索联合CPAP治疗OSAHS合并RLS患者睡眠障碍安全、有效。 |
| 关 键 词： | 普拉克索 连续气道正压通气 睡眠呼吸暂停,阻塞性 睡眠呼吸暂停综合征 不宁腿综合征 |
Observation of pramipexole joint with continuous positive airway pressure in treating obstructive sleep apnea hypopnea syndrome combined with restless legs syndrome |
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| JIANG Hai-bo,YE Xiao-jun,RUAN Zhao-yang,WANG Xiao-chuan. Observation of pramipexole joint with continuous positive airway pressure in treating obstructive sleep apnea hypopnea syndrome combined with restless legs syndrome[J]. Chinese Journal of New Drugs and Clinical Remedies, 2011, 0(10) | |
| Authors: | JIANG Hai-bo YE Xiao-jun RUAN Zhao-yang WANG Xiao-chuan |
| Affiliation: | JIANG Hai-bo,YE Xiao-jun,RUAN Zhao-yang,WANG Xiao-chuan(Department of Neurology,the Affiliated Hospital of Hangzhou Normal University,Hangzhou ZHEJIANG 310015,China) |
| Abstract: | AIM To observe the therapeutic effect of pramipexole joint with continuous positive airway pressure(CPAP)in treating obstructive sleep apnea hypopnea syndrome(OSAHS)combined with restless legs syndrome(RLS).METHODS Forty patients suffered from OSAHS combined with RLS were randomly divided into control group and treatment group(n = 20).Based on the CPAP,the control group was treated with placebo qn.and the treatment group was treated with pramipexole 0.125 mg qn.for 6 months.The apnea hypopnea index(AHI),per... |
| Keywords: | pramipexole continuous positive airway pressure sleep apnea obstructive sleep apnea syndromes restless legs syndrome |
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