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| 大黄酚固体分散体对镉染毒大鼠氧化应激影响 | |
| 引用本文： | 韩刚,阚佳妮,王成强,赵媛,郭肖菲,包书茵. 大黄酚固体分散体对镉染毒大鼠氧化应激影响[J]. 中国职业医学, 2011, 38(6) |
| 作者姓名： | 韩刚 阚佳妮 王成强 赵媛 郭肖菲 包书茵 |
| 作者单位： | 河北联合大学药学院,河北唐山,063000 |
| 基金项目： | 国家自然科学基金资助项目(30170799); 国家教育部博士点基金资助项目(20010001092) |
| 摘 要： | 目的 观察大黄酚固体分散体对镉染毒大鼠氧化损伤的影响.方法 以聚乙二醇6 000为载体制备大黄酚固体分散体,差示扫描量热法(DSC)和X射线衍射法对固体分散体进行分析.SD大鼠40只,雌雄各半,随机分为5组,分别为正常对照组、镉染毒组、镉加大黄酚组、镉加大黄酚固体分散体低剂量组和镉加大黄酚固体分散体高剂量组.正常对照组灌胃纯净水,其余4组给予20 mg/kg氯化镉隔日灌胃染毒,共染毒4次,染毒6h后给予大黄酚或大黄酚固体分散体干预.末次给药后,测定大鼠血清、脑和肾中超氧化物歧化酶(SOD)活力及丙二醛(MDA)水平,测定大鼠血清谷胱甘肽过氧化物酶(GSH-Px)、丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)活力.结果 DSC和X射线衍射分析表明,大黄酚以无定形形式存在于固体分散体中.大黄酚固体分散体可降低镉染毒大鼠血清、脑组织和肾中MDA水平(P＜0.05),增加血清、脑组织和肾中SOD和GSH-Px活力(P＜0.05),降低血清中ALT、AST活力(P＜0.05).结论 大黄酚固体分散体可降低镉对大鼠造成的肝损伤、脑损伤和氧化损伤. |
| 关 键 词： | 大黄酚 固体分散体 镉 氧化应激 大鼠 |
Effect of chrysophanol solid dispersion on oxidative stress induced by cadmium in rats |
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| HAN Gang , KAN Jia-ni , WANG Cheng-qiang , ZHAO Yuan , GUO Xiao-fei , BAO Shu-yin. Effect of chrysophanol solid dispersion on oxidative stress induced by cadmium in rats[J]. China Occupational Medicine, 2011, 38(6) | |
| Authors: | HAN Gang KAN Jia-ni WANG Cheng-qiang ZHAO Yuan GUO Xiao-fei BAO Shu-yin |
| Affiliation: | HAN Gang,KAN Jia-ni,WANG Cheng-qiang,ZHAO Yuan,GUO Xiao-fei,BAO Shu-yin (Pharmaceutical College of Hebei United University,Tangshan 063000,China) |
| Abstract: | Objective To observe the effects of chrysophanol solid dispersion to oxidative stress induced by cadmium in rats. Methods Chrysophanol solid dispersion was made by polyethylene glycol 6 000 vector and analyzed by differential scanning calorimetry(DSC) and X-ray diffraction method.40 SD rats were randomly divided into 5 groups,including normal control group,cadmium exposure group,cadmium and chrysophanol group,low dosage of cadmium and chrysophanol solid dispersion group,high dosage of cadmium and chrysophan... |
| Keywords: | Chrysophanol Solid dispersion Cadmium Oxidative stress Rat |
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