Serological and molecular analysis of HLA class I and II alleles in Thai patients with psoriasis vulgaris |
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| Authors: | S. Vejbaesya T.H. Eiermann P. Suthipinititharm C. Bancha H.A.F. Stephens K. Luangtrakool D. Chandanayingyong |
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| Affiliation: | Department of Transfusion Medicine, Siriraj Hospital, Mahidol University, Bangkok. Thailand;Department of Transfusion Medicine, University Hospital Eppendorf, Hamburg, Germany;Department of Dermatology, Siriraj Hospital, Mahidol University, Bangkok, Thailand |
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| Abstract: | ![]()
Abstract: The HLA class I and class II alleles in 67 patients with type I psoriasis vulgaris, 23 patients with type II psoriasis vulgaris and 140 healthy individuals were analyzed. The frequencies of HLA-A2, -B46, -B57 and DQB1*0303 were significantly increased in type I psoriasis compared to the controls (Pc<0.05). Molecular analysis of HLA-A2 alleles showed an increase in HLA-A*0207 and a decrease in HLA-A*0203 in type I psoriasis. HLA-DQBl*0301 was significantly decreased in type I psoriasis compared to the normal controls (Pc<0.05). No association of any alleles with type II psoriasis was observed. This data demonstrated two susceptible haplo-types: HLA-A1-B57-DRB1*0701-DQA1*0201-DQB1*0303 (AH57.1) and HLA-A2-B46-DRB1*0901-DQA1*0301-DQB1*0303 (AH46.1) for type I psoriasis in the Thai population. Besides, the haplotype AH46.1 was also associated with type II psoriasis. |
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| Keywords: | HLA class I HLA class II psoriasis vulgaris |
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