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| 洛伐他汀治疗小儿肾病综合征高脂血症的观察 | |
| 引用本文： | 韩子明,陈新德,张贺,杨达胜. 洛伐他汀治疗小儿肾病综合征高脂血症的观察[J]. 中国综合临床, 2001, 17(8): 632-633 |
| 作者姓名： | 韩子明 陈新德 张贺 杨达胜 |
| 作者单位： | 新乡医学院第一附属医院儿科 |
| 摘 要： | 目的：观察洛伐他汀治疗小儿肾病综合征高旨血症的疗效。方法：43例小儿肾病综合征随机分为治疗组和对照组，治疗组21例，对照组22例，均应用强的松，治疗组加用洛伐他汀。；治疗前及治疗后1月分别检查肝功能及血脂。结果：各组治疗前后比较ApoB,TC,TG,LDL-C,Lpa明显下降（P＜0．01）。治疗组ApoB,TC,TG,LDL-C较对照组明显降低（P＜0．01），而Lpa无明显显差异（P＜0．05）。结论洛汀能有效降低小儿肾病综合征的血脂水平。 |
| 关 键 词： | 肾病综合征 洛伐他汀 高脂血症 药物疗法 儿童 治疗 |
| 文章编号： | 1008-6315(2001)08-0632-02 |
| 修稿时间： | 2001-03-14 |
The observation of effect of lovastatin on hyperlipidemia of children with nephrotic syndrome |
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| Han Ziming,Chen Xinde,Zhang He,et al.. The observation of effect of lovastatin on hyperlipidemia of children with nephrotic syndrome[J]. Clinical Medicine of China, 2001, 17(8): 632-633 | |
| Authors: | Han Ziming Chen Xinde Zhang He et al. |
| Affiliation: | Han Ziming,Chen Xinde,Zhang He,et al.Department of Pediatrics,First Affiliated Hosptial of Xinxiang Medical College,Weihui 453100 |
| Abstract: | Objective To investigate the effect of lovastatin on hyperlipemia of children with nephrotic syndrom.Methods 43 cases of nephrotic syndrome were randomly divided into treatment group (n=21) and control group (n=22), all of which were given prednisone.Lovastatin was added to the treatment group.Before treatment and one month after treatment liver function and serum lipide were measured.Results The levels of serum apolipoprotein B (ApoB),total cholesterol (TC), trigtycerides (TG), low density lipoprotein cholesterol (LDL C) and lipoprotein (a) (Lpa) were obviously decreased compared with that before treament (P<0.01).The concentrations of serum ApoB,TC,TG and LDL C in treatment group were much lower than that in control group (P<0.01) and there was no obvious difference in Lp(a) between the two groups.Conclusion Lovastatin can obviously decrease the level of serum lipide in children with nephrotic syndrome. |
| Keywords: | Nephrotic syndrome Children Lovasatin Low lipide therapy |
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