| 体外循环中氧分压对紫绀型心脏病心肌过氧化反应的影响 |
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| 引用本文： | 陈萍,章晓华,黄劲松,郭阳娇,宋兴荣,黄克力.体外循环中氧分压对紫绀型心脏病心肌过氧化反应的影响[J].岭南心血管病杂志,2008,14(6). |
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| 作者姓名： | 陈萍 章晓华 黄劲松 郭阳娇 宋兴荣 黄克力 |
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| 作者单位： | 广东省人民医院广东省心血管病研究所心脏外科,广州,510080 |
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| 基金项目： | 广东省自然科学基金
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| 摘 要： | 目的探讨体外循环不同梯度动脉血氧分压(arterial oxygen partial pressure,PaO2)对紫绀型先天性心脏病心肌过氧化反应的影响。方法3岁以下经皮血氧饱和度(oxigen saturation,SpO2)低于0.85、行根治术的法洛四联症患儿90例,随机分为3组:实验1组(1组,n=30)以接近患儿术前水平的低氧分压启动体外循环并控制血流复温前的PaO2(≤130mmHg)(1mmHg=0.133kPa),体外循环血流复温时使PaO2逐渐升至250～300mmHg;实验2组(2组,n=30)体外循环中PaO2在250～300mmHg启动体外循环,血流复温后使PaO2逐渐升至450～500mmHg;对照组(n=30)体外循环中PaO2始终控制在450～500mmHg。于体外循环前、主动脉开放后取右心房组织测量心肌过氧化反应指标:①超氧化物歧化酶和丙二醛;②谷胱甘肽过氧化物酶活性;③总抗氧化能力。结果①体外循环前各组心肌组织超氧化物歧化酶和丙二醛差异无统计学意义;体外循环后,1组超氧化物歧化酶显著高于对照组,丙二醛低于对照组;2组超氧化物歧化酶高于对照组低于1组,MDA低于对照组高于1组...
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| 关 键 词： | 先天性心脏病 体外循环 心肌抗氧化能力氧分压 |
Effects of arterial oxygen partial pressures during cardiopulmonary bypass on myocardial antioxidant capacity in cyanotic heart diseases |
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| CHEN Ping,ZHANG Xiao-hua,HUANG Jing-song,GUO Yang-jiao,SONG Xing-rong,HUANG Ke-li.Effects of arterial oxygen partial pressures during cardiopulmonary bypass on myocardial antioxidant capacity in cyanotic heart diseases[J].South China Journal of Cardiovascular Diseases,2008,14(6). |
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| Authors: | CHEN Ping ZHANG Xiao-hua HUANG Jing-song GUO Yang-jiao SONG Xing-rong HUANG Ke-li |
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| Institution: | CHEN Ping,ZHANG Xiao-hua,HUANG Jing-song,GUO Yang-jiao,SONG Xing-rong,HUANG Ke-li(Department of Cardiovascular Surgery,Guangdong Provincial Genernal Hospital,Guangzhou 510080,China) |
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| Abstract: | Objectives To evaluate the effects of different arterial oxygen partial pressures(PaO2) on myocardial antioxidant capacity in cyanotic heart diseases.Methods Ninety children suffering from tetrallogy of Fallot(TOF) under 3 years of age with oxigen saturation less than 0.85 undergoing one-stage repairing operations were divided into 3 groups,experimental group 1(G1,n =30),PaO2 at the beginning and during cardiopulmonary bypass(CPB) was maintained below 130 mm Hg before blood rewarming;experimental group 2(G2... |
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| Keywords: | Congenital heart disease Cardiopulmonary bypass Myocardial antioxidant capacity Oxygen partial pressure |
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