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| 脂质过氧化抑制剂对大鼠肾脏低温保存和移植的保护作用 | |
| 引用本文： | 王春友,润晓勤,万赤丹,张景辉. 脂质过氧化抑制剂对大鼠肾脏低温保存和移植的保护作用[J]. 中华器官移植杂志, 2001, 22(2): 97-99 |
| 作者姓名： | 王春友 润晓勤 万赤丹 张景辉 |
| 作者单位： | 华中科技大学同济医学院协和医院普通外科 |
| 基金项目： | 国家自然科学基金资助项目（39670704） |
| 摘 要： | 目的：探讨脂质过氧化反应对肾脏低温保存和移植的影响及其作用机制。方法：对大鼠肾脏低温保存和移植前进行脂质过氧化抑制预处理，观察移植肾脏功能和形态的变化，肾组织丙二醛（MDA）含量及白细胞介素－2（IL－2）、细胞间粘附分子－1（ICAM－1）、诱导型一氧化氮合酶（iNOS)的表达水平。结果：与对照组相比，治疗组肾脏形态和功能的异常均减轻，IL－2、ICAM－1、iNOS的表达水平和MDA含量明显降低，结论脂质过氧化抑制剂可减轻细胞脂质过氧化反应，对移植肾脏的形态和功能起到保护作用。 |
| 关 键 词： | 脂质过氧化反应 肾移植 肾脏 低温保存 脂质过氧化抑制剂 |
Protective effect of lipid peroxidation inhibitor on rat kidneys during cold storage and transplantation |
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| WANG Chunyou,RUN Xiaoqin,WAN Chidan,et al.. Protective effect of lipid peroxidation inhibitor on rat kidneys during cold storage and transplantation[J]. Chinese Journal of Organ Transplantation, 2001, 22(2): 97-99 | |
| Authors: | WANG Chunyou RUN Xiaoqin WAN Chidan et al. |
| Affiliation: | WANG Chunyou,RUN Xiaoqin,WAN Chidan,et al. Department of General Surgery,The Affiliated Xiehe Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,China |
| Abstract: | Objective To investigate the effect and mechanism of lipid peroxidation on rat kidneys during cold storage and transplantation.Methods Lipid peroxidation inhibitor was administrated once prior to kidney harvesting and again before reperfusion. Expression of IL 2, iNOS, ICAM 1 were detected by RT PCR. MDA concentration, renal function and morphology were also studied. Results Abnormality of renal function and morphology were alleviated in the treated group as compared with control group. MDA concentration and the expression levels of IL 2, ICAM 1, iNOS in the treated group were also reduced.Conclusion Lipid peroxidation inhibitor could reduce lipid peroxidation and had significant protection during renal cold preservation and transplantation. |
| Keywords: | Lipid peroxidation Kidney Preservation Transplantation |
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