Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma |
| |
Authors: | Akihito Fujimi Yusuke Kamihara Yuji Kanisawa Akari Hashimoto Chisa Nakajima Naotaka Hayasaka Naoki Uemura Toshinori Okuda Shinya Minami Satoshi Iyama Koichi Takada Tsutomu Sato Akinori Hara Yasunori Iwata Kengo Furuichi Takashi Wada Junji Kato |
| |
Affiliation: | 1. Department of Hematology and Oncology, Oji General Hospital, 3-4-8 Wakakusa-Cho, Tomakomai, 053-8506, Japan 2. Department of Gastroenterology, Oji General Hospital, Tomakomai, Japan 3. Department of Medical Oncology and Hematology, Sapporo Medical University, Sapporo, Japan 4. Division of Nephrology, Kanazawa University Hospital, Kanazawa, Japan
|
| |
Abstract: | ![]() A 79-year-old female diagnosed with T cell/histiocyte-rich large B cell lymphoma in complete remission after six cycles of rituximab-combined chemotherapy developed severe anemia, reticulocytopenia, and bone marrow erythroid hypoplasia. She was diagnosed with pure red cell aplasia (PRCA) accompanied by Coombs-negative autoimmune hemolytic anemia evidenced by a lack of glycophorin-A-positive cells in the bone marrow, haptoglobin under the detection level, and a high titer of RBC-bound IgG. Anti-erythropoietin receptor (EPOR) antibody was detected in the serum, and oligoclonal α/β and γ/δ T cells were also detected in her peripheral blood by Southern blotting analysis. Parvovirus B19 DNA was not detected by PCR. Although the treatment with rituximab had limited efficacy (specifically, only for hemolysis), subsequent cyclosporine therapy led to prompt recovery of erythropoiesis with the disappearance of anti-EPOR antibody and oligoclonal T cells. This is the first case report of anti-EPOR antibody-associated PRCA in a patient with malignant lymphoma treated successfully with cyclosporine. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|