| 紫杉醇和三尖杉磷碱在多孔硅胶上的吸附及扩散研究 |
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| 引用本文： | 杨军,郝雅琳.紫杉醇和三尖杉磷碱在多孔硅胶上的吸附及扩散研究[J].医学教育探索,1999(10):735-739. |
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| 作者姓名： | 杨军 郝雅琳 |
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| 作者单位： | ：天津大学天然产物工程研究中心 300072 |
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| 基金项目： | 国家教委“跨世纪优秀人才培养计划”和教委优秀青年教师基金 |
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| 摘 要： | 吸附和扩散特性是进行色谱过程的基础，本文测定了紫杉醇及其类似物的三尖杉磷碱在多孔的吸附及扩散特性，结果表明：紫杉醇和三尖杉磷酸在硅胶上的吸附不符合Ｌａｎｇｍｕｉｒ单分子层吸附理论，但在低浓度下可用溶剂调整型Ｌａｎｇｍｕｉｒ模型描述。扩散研究表明，用醇和三尖彬磷碱在硅胶上吸附罗弱，表面扩散可以忽略，相同条件下，紫杉醇的吸附量受强溶剂影响罗大，强溶剂组成的增加会造成紫杉醇吸附量很快下降，这和在正相色谱
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| 关 键 词： | 紫杉醇 三尖杉磷碱 吸附 扩散 抗癌药 |
Studies on the Adsorption and Diffusivity of Paclitaxel and Cephalomanine on Porous Gel |
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| Yang Jun,Hao Yalin,and Yuan Yingjin.Studies on the Adsorption and Diffusivity of Paclitaxel and Cephalomanine on Porous Gel[J].Researches in Medical Education,1999(10):735-739. |
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| Authors: | Yang Jun Hao Yalin and Yuan Yingjin |
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| Institution: | Yang Jun, Hao Yalin and Yuan
Yingjin ;
(The Natural Product Research Center of Tianjin University,Tianjin 300072) |
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| Abstract: | Adsorption and diffusivity behavior of paclitaxel and cephalomanine on porous gel during chromatographic separation were studied. Results showed that their adsorption did not follow Langmuir model, but at low concentrations of the solute, the solvent modulated Langmuir model could be followed and gave satisfactory results. As to their diffusivity, the rate on the surface of the absorbent could be negelected due to the fact that both paclitaxel and cephalomanine were very little adsorbed. Under the same condition, the increase of strong solvent resulted in a greater influence on the adsorption of paclitaxel by decreasing its adsorption rapidly as compared with cephalomanine. |
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| Keywords: | paclitaxel cephalomanine adsorption diffusivity |
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