Evaluation of Anti-Bacterial and Wound Healing Activity of the Fruits of Amorpha Fruticosa L. |
| |
| Authors: | Xueling Qu Yunpeng Diao Zhen Zhang Shouyu Wang Yujie Jia |
| |
| Institution: | 1.Department of Pathophysiology, Dalian Medical University, Dalian, Liaoning Province, China 116011;2.Department of Pharmacy, Dalian Medical University, Dalian, Liaoning Provinc, China 116011;3.Department of Orthopedic Surgery, First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning Province, China 116011 |
| |
| Abstract: | As the traditional Chinese medicine, the fresh fruits of Amorpha fruticosa L. were applied for the treatment of carbuncle, eczema and burn (Das et al., 2007). However, little is known about the functional roles of the fruits of Amorpha fruticosa L. during wound healing progress. In the present study, we evaluated both antimicrobial potential against a wide range of microorganisms and wound healing activity of the seven compounds isolated from the fruits of Amorpha fruticosa L in vitro and in vivo. Our results showed that compounds I (6a,12a-dehydroamorphin), V (dehydrosermundone) and VI (tephrosin) isolated from the fruits of Amorpha fruticosa L. performed dominant antimicrobial potential against microorganisms. Moreover, these compounds significantly enhanced fibroblasts proliferation and migration, leading to promotion of wound healing. Thus, it could be possible for the therapeutic utilization of Amorpha fruticosa L. for wound healing in the future. |
| |
| Keywords: | Amorpha fruticosa L anti-bacterial wound healing |
|
|
