| 肿瘤相关巨噬细胞与肿瘤关系的研究进展 |
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| 引用本文： | 吴红梅,齐蕾,单丽辉,柴翠翠,王立峰. 肿瘤相关巨噬细胞与肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2014, 28(3): 258-262 |
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| 作者姓名： | 吴红梅 齐蕾 单丽辉 柴翠翠 王立峰 |
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| 作者单位： | 1.哈尔滨医科大学附属第一临床医院病理科（150001）；2.河北省邢台市人民医院病理科 ；3哈尔滨市第五医院病理科 |
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| 摘 要： | 肿瘤相关巨噬细胞（ Tumor associate macrophages ，TAMs）是肿瘤的炎症微环境与肿瘤细胞间的重要信使。它是从血液中的单核细胞演变而来，主要通过集落刺激因子（ Colony -stimulating factor ， CSF）趋化至肿瘤组织中。本文简述了TAMs通过影响血管生成和淋巴管生成，抑制免疫，调节基质，与干细胞相互作用等方面促进肿瘤的进展。分析表明靶向于TAMs的治疗策略是未来治疗肿瘤的一个新方向。
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| 关 键 词： | 肿瘤相关巨噬细胞 血管生成 肿瘤干细胞 肿瘤微环境 |
| 收稿时间： | 2014-06-25 |
The role of tumor associated macrophages in tumor progression |
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| WU Hongmei,QI Lei,SHAN Lihui,CHAI cuicui,WANG Lifeng. The role of tumor associated macrophages in tumor progression[J]. Journal of Practical Oncology, 2014, 28(3): 258-262 |
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| Authors: | WU Hongmei QI Lei SHAN Lihui CHAI cuicui WANG Lifeng |
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| Affiliation: | 1. Department of Pathology,The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China; 2. Department of Pathology, People＇ s Hospital of Xingtai City ; 3. Department of Pathology, The Fifth Hospital of＇ Harbin ;4. Department of Pathology, People＇s Hospital of Pingshan District of Shenzhen) |
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| Abstract: | Tumor associate macrophages （ TAMs） play a significant role in the interaction of tumor inflam-mative microenvironment and tumor cells .TAMs originate from monocytic precursors ,recruiting into tumor tissue by colony stimulating factor （ CSF） .This review summarized that TAMs promote tumor progression and metastasis though angiogenesis ,lymphogenesis , immunosuppression , matrix remodeling and affecting cancer stem cells .The article pointed that targeting TAMs is a new strategy for future tumor therapy . |
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| Keywords: | Tumor associated macrophages Angiogenesis Cancer stem cells Tumor microenvironment |
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