| 川芎嗪与人血清白蛋白结合的荧光法测定 |
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| 引用本文： | 洪馨,宓穗卿,徐志勇. 川芎嗪与人血清白蛋白结合的荧光法测定[J]. 中药新药与临床药理, 2005, 16(3): 212-214 |
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| 作者姓名： | 洪馨 宓穗卿 徐志勇 |
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| 作者单位： | 广州中医药大学临床药理研究所,广州,510405 |
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| 摘 要： | 目的研究川芎嗪与人血清白蛋白的作用.方法采用荧光法测定了川芎嗪对人血清白蛋白荧光的猝灭.结果根据荧光测定的结果,得到川芎嗪与人血清白蛋白的形成常数.结论川芎嗪与人血清白蛋白能形成复合物.
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| 关 键 词： | 川芎嗪 人血清白蛋白 荧光法 相互作用 |
| 文章编号： | 1003-9783(2005)03-0212-02 |
| 修稿时间： | 2004-10-28 |
Fluorimetric Determination of the Complex of Tetramethylpyrazine and Human Serum Albumin |
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| HONG Xin,MI Suiqing,Xu Zhiyong. Fluorimetric Determination of the Complex of Tetramethylpyrazine and Human Serum Albumin[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2005, 16(3): 212-214 |
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| Authors: | HONG Xin MI Suiqing Xu Zhiyong |
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| Abstract: | Objective To study the interaction of tetramethylpyrazine and human serum albumin(HSA).Methods The fluorescent quenching of HSA with te tramethylpyrazine has been detecte d by fluorimetry.Results It was found that fluo-rescence of HSA were quenched by tetr amethylpyrazine.The fluorescent q uenching data were analyzed accordi ng to Stern -volmer equation and the bindi ng constant was obtained.Conclusion The mechanism of fluorescent quench ing is considered to be the formation of HSA-tetramethylpyrazine complex. |
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| Keywords: | Tetramethylpyrazine Human serum albumin Fluorescence Interaction |
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