| 取代苯亚硒酸的合成及抗癌活性研究 |
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| 引用本文： | 郑时龙,胥佩菱. 取代苯亚硒酸的合成及抗癌活性研究[J]. 四川大学学报(医学版), 1995, 0(4) |
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| 作者姓名： | 郑时龙 胥佩菱 |
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| 摘 要： | ![]()
根据硒与癌症的负相关关系和有机硒的生物活性可能更高，作者设计并合成了十一个取代苯亚硒酸化合物（Ⅳ＿（ａ～ｋ）。化合物经抑制乙酰胆碱脂酶，体外抗ＨＬ－６０和Ｋ５６２及抑制小鼠艾氏腹水癌实验，发现Ⅳ＿ａ和Ⅳ＿ｂ有较强的活性。Ⅳ＿ｂ抑制小鼠艾氏腹水癌的抑瘤率为２０．３０％（２０ｍｇ／ｋｇ），高于亚硒酸钠的１０．６５％（０．５ｍｇ／ｋｇ）。
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| 关 键 词： | 取代苯亚硒酸，合成，抗癌活性 |
Synthesis of Substituted Benzeneseleninic Acid and Its Antineoplastic Activity |
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| Zheng Shilong, Xu Peiling. Synthesis of Substituted Benzeneseleninic Acid and Its Antineoplastic Activity[J]. Journal of Sichuan University. Medical science edition, 1995, 0(4) |
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| Authors: | Zheng Shilong Xu Peiling |
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| Affiliation: | Department of Organic Chemistry |
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| Abstract: | ![]()
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| Keywords: | Substituted benzeneseleninic acid Synthesis Antineoplastic activity The project Supported by National Natural Science Foundation of China |
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