|
|||||
|
|
| 奥美拉唑镁肠溶片含量测定方法的改进 | |
| 引用本文： | 孙蕊,刘世超. 奥美拉唑镁肠溶片含量测定方法的改进[J]. 中国医药导报, 2011, 8(1): 61-63 |
| 作者姓名： | 孙蕊 刘世超 |
| 作者单位： | 1. 河南省洛阳市中心医院药剂科,河南,洛阳,471009 2. 河南省洛阳市妇女儿童医疗保健中心药剂科,河南,洛阳,471000 |
| 摘 要： | 目的：建立高效液相法测定奥美拉唑镁肠溶片含量的方法。方法：采用Diamonsil C18（4．6mm×150mm，5μm）色谱柱：流动相：甲醇-水-磷酸-三乙胺（65：35：0．12：0．3）；检测波长：302nm；流速：1．0ml／min。结果：奥美拉唑镁在13．3182～31．0758μg范围内与峰面积呈良好的线性关系（r=0．9990），平均回收率为101．14％，RSD=1．64％。结论：本法简便、准确、重现性好．可用于奥美拉唑镁肠溶片的质量控制。 |
| 关 键 词： | 高效液相法 奥美拉唑镁 奥美拉唑镁肠溶片 含量测定 |
Improve method for the content determination of Omeprazole Magnesium Enteric-coared Tablets |
|
| SUN Rui,LIU Shichao. Improve method for the content determination of Omeprazole Magnesium Enteric-coared Tablets[J]. China Medical Herald, 2011, 8(1): 61-63 | |
| Authors: | SUN Rui LIU Shichao |
| Affiliation: | SUN Rui1,LIU Shichao2 (1.Department of Pharmacy,the Center Hospital of Luoyang City,Luoyang 471009,China,2.Department of Pharmacy,Woman and Children Health Care Center in Luoyang City,Luoyang 471000,China) |
| Abstract: | Objective： To establish a method for the content determination of Omeprazole Magnesium in Omeprazole Mag nesium Enteric-coated Tablets by HPLC. Methods： The Diamonsil-Cis （4.6 mm×150mm, 5 μm） column was used. The mo bile phases consisted of methanol, water, phosphoric acid and triethylamine （65：35：0.12：0.3）, the flow rate was 1.0 ml/min and the detection wavelength was at 302 nm. Results： The linear ranges of Omeprazole was at 13.318 2-31.075 8 μg （r=0.999 0）, the average recovery was 101.14% with a RSD of 1.64%. Conclusion： The method is fast, reliable, accurate and can be used in the quality control of Omeprazole Magnesium in Omeprazole Magnesium Enteric-coared Tablets. |
| Keywords: | HPLC Omeprazole Magnesium Omeprazole Magnesium Enteric-coared Tablets Content determination |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |