| 3-羧酸碳青霉烯和硫霉素的生物合成研究进展 |
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| 引用本文： | 黄娟娟,李继安,付骋宇,邵雷.3-羧酸碳青霉烯和硫霉素的生物合成研究进展[J].药学进展,2011,35(1):8-14. |
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| 作者姓名： | 黄娟娟 李继安 付骋宇 邵雷 |
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| 作者单位： | 1. 上海医药工业研究院创新药物与制药工艺国家重点实验室,上海,200437
2. 陕西出入境检验检疫局,西安,710068 |
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| 基金项目： | 国家重大新药创制科技重大专项 |
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| 摘 要： | 3-羧酸碳青霉烯和硫霉素均属β-内酰胺类抗生素,具有重要的临床应用价值.讨论3-羧酸碳青霉烯和硫霉素的生物合成途径和影响因素,并介绍一些相关的新化合物,旨在为改进该类抗生素的发酵条件及利用组合生物合成技术创制新药提供参考和思路.
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| 关 键 词： | 碳青霉烯 生物合成 3-羧酸碳青霉烯 硫霉素 |
Advances in Research on Biosynthesis of (5R)-carbapenem-3-carboxylic Acid and Thienamycin |
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| HUANG Juan-juan,LI Ji-an,FU Cheng-yu,SHAO Lei.Advances in Research on Biosynthesis of (5R)-carbapenem-3-carboxylic Acid and Thienamycin[J].Progress in Pharmaceutical Sciences,2011,35(1):8-14. |
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| Authors: | HUANG Juan-juan LI Ji-an FU Cheng-yu SHAO Lei |
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| Institution: | 1* (1.State Key Lab of New Drug and Pharmaceutical Process,Shanghai Institute of Pharmaceutical Industry,Shanghai 200437,China;2.Shanxi Entry-Exit Inspection and Quarantine Bureau,Xi′an 710068,China) |
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| Abstract: | （5R）-carbapenem-3-carboxylic acid and thienamycin are members of the β-lactam family antibiotics and they are very important in clinical use.The advances in research on the biosynthesis and the related adjusting facts of（5R）-carbapenem-3-carboxylic acid and thienamycin,and some new compounds were briefly introduced,so as to provide references and thoughts for optimizing fermentation conditions of this kind of antibiotics and synthesizing new compounds by combinatorial biosynthetic technique. |
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| Keywords: | carbapenem biosynthesis （5R） -carbapenem-3-carboxylic acid thienamycin |
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