| 熊果酸衍生物构效关系研究进展 |
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| 引用本文： | 李彩莲,冯锋. 熊果酸衍生物构效关系研究进展[J]. 药学进展, 2011, 35(1): 23-29. DOI: 10.3969/j.issn.1001-5094.2011.01.004 |
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| 作者姓名： | 李彩莲 冯锋 |
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| 作者单位： | 中国药科大学天然药物化学教研室,江苏,南京,210009 |
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| 摘 要： | 综述了近年来对熊果酸的结构修饰及其衍生物构效关系的研究进展。熊果酸是一种广泛存在于天然植物中的五环三萜类化合物,具有抗肿瘤、降血糖、抗炎、抗HIV等药理活性,故而受到研究人员的广泛关注。对熊果酸进行结构修饰及构效关系探索,以获得高效低毒的候选化合物,已成为该化合物的研究热点之一。
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| 关 键 词： | 熊果酸 结构修饰 构效关系 |
Advances in Research on Structure-activity Relationships of Ursolic Acid Derivatives |
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| LI Cai-lian,FENG Feng. Advances in Research on Structure-activity Relationships of Ursolic Acid Derivatives[J]. Progress in Pharmaceutical Sciences, 2011, 35(1): 23-29. DOI: 10.3969/j.issn.1001-5094.2011.01.004 |
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| Authors: | LI Cai-lian FENG Feng |
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| Affiliation: | (Department of Phytochemistry,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | The advances in research on the structural modification of ursolic acid and the structure-activity relationships（SARs） of ursolic acid derivatives were reviewed in this paper.Ursolic acid is a kind of pentacyclic triterpenoid which is widely found in natural plants and has a variety of pharmacological acti-vities such as anti-tumor activity,anti-diabetic activity,anti-inflammatory activity and anti-HIV activity.Therefore,it has been paid a great attention by more and more researchers.The research on the structural modification of ursolic acid and the SARs of ursolic acid derivatives has become a hotspot,from which the ideal candidate compounds might be aquired. |
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| Keywords: | ursolic acid structural modification ：structure-activity relationship |
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