缺血性股骨头坏死患者血清透明质酸及层粘连蛋白的研究

为探讨细胞外间质主要成分透明质酸（ＨＡ）与层粘连蛋白（ＬＮ）在缺血性股骨头坏死（ＩＮＦＨ）中的生理病理过程及临床价值，采用放射免疫分析法对４５例不同病因的ＩＮＦＨ患者进行了血清ＨＡ与ＬＮ的定量分析，并与３０例正常人对照。结果显示，ＩＮＦＨ患者血清ＨＡ含量极显著地高于对照组（ｔ＝３－２９；Ｐ＜０－０１）。尤以激素性ＩＮＦＮ增高最为显著（ｔ＝３－６２；Ｐ＜０－０１）。ＩＮＦＨ患者ＬＮ含量亦明显高于对照组（ｔ＝２－８４；Ｐ＜０－０１）。同时，ＨＡ与ＬＮ含量增高与病程发展密切相关。故定量检测ＨＡ与ＬＮ可作为ＩＮＦＨ早期诊断及判断预后的良好指标

Hyaluronic Acid and Laminin in Patients with Ischemic Necrosis of Femoral Head

To study the course and clinical significance of hyaluronic acid (HA) and laminin(LN),the main components of extracellular matrix in ischemic necrosis of femoral head(INFH),the quantities of HA and LN were measured by radioimmunoassay in 45 patients suffering from INFH with different pathogenesis,and in 30 normal subjects(NS).The results showed that the level of HA in patients with INFH was markedly higher than that of NS group(t=3.29, P <0 01).The patients with hormone type INFH had the highest level of HA(t=3.62, P <0 01).The level of LN in patient with INFH was significantly higher than that of NS group(t=2.84, P <0 01).The increased levels of HA and LN were positively correlated with the development of the disease.These suggest that quantity analysis of HA and LN may be used as a good indicator in early diagnosis and prognosis of INFH.