原发性肝癌298例临床回顾分析

 我科1960～1986年底共收治原发性肝癌患者298例。其中297例属中晚期。全身给药223例(全身组),肝动脉插管灌注化疗药75例(插管组),药物以化疗药(MMC、5Fu,TspA等)及抗癌中草药单用或联合用药为主,少部分病例加用放疗和/或中药综合治疗。本组总有效率11.1%,插管组CR+PR为32%,全身组为4%,P＜0.001。生存期则前者优于后者,两组疗后存活小于3个月者为38.7%与64.5%,P＜0.01,疗后生存期超过7个月者为30.7%与18.4%,P＜0.01。中位生存期有效者9.25个月,无效者3.33个月,P＜0.001;疗后生存期超过12个月者共26例。毒性反应主要有(口恶)心、呕吐、骨髓抑制、肝功损害等,未发生与药物毒性有关的死亡。本文讨论了原发性肝癌治疗及影响生存期的因素。

CLINICAL ANALYSIS OF 298 CASES OF PRIMARY LIVER CANCER

From 1960 through 1980, 298 cases of primary liver oancer were treated in our hospital. Of them, 297 cases had moderately advsnced and advanced lesions. These patients were divided into two groups: Group 1, chemotherapy by intravenous, intramuscular or oral routes in 223 cases; Group 2, intra-arterial infusion chemotherapy in 75. Some patients were added with radiotherapy and/or traditional Chinese medicine. The total response rate was 11.1%. In Group 1, partial response rate was 4%while in Group 2, complete plus partial response rates were 32% (P0.001). Patients who survied for less than 3 months after treatment were 64.5% and 38.7% and those who Survived for over 7months were 18.4% and 30.7% in Groups 1 and 2 (P0.01). Twenty six patients survived for more than 1 year. The median survival was 9.25 and 3.33 months in the responders and non-responders (P0.001). The main side effects were nausea, vomitting, bone marrow supression and damage of liver function, etc. No mortality was ascribed to the side effects ot chemotherapy.