| 抑郁症的静息态脑功能磁共振研究 |
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| 引用本文： | 李东明,黄晓琦,吴杞柱,邹可,孙学礼,龚启勇.抑郁症的静息态脑功能磁共振研究[J].生物医学工程学杂志,2010(1). |
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| 作者姓名： | 李东明 黄晓琦 吴杞柱 邹可 孙学礼 龚启勇 |
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| 作者单位： | 四川大学华西医院放射科磁共振中心(HMRRC);四川大学华西医院心理卫生中心; |
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| 基金项目： | “十五”国家科技攻关资助项目(2004BA720A21-01); 高等学校博士学科点专项科研基金资助项目(20060610073); 新教师基金资助项目(20070610153) |
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| 摘 要： | 本研究的目的是研究抑郁症患者与健康人静息态脑功能的差别。对符合DSM-IV诊断标准的53例抑郁症患者和38例正常对照进行静息态功能磁共振扫描,采用局部一致性(regional homogeneity,ReHo)的方法分析数据,然后进行基于体素的组间比较,分析其静息态脑功能的差异。结果显示与正常组相比,抑郁组在双侧前扣带皮质(anterior cingulate cortex,ACC)、左侧内侧前额叶皮质、左侧颞中回均有ReHo值降低。ACC位置ReHo值显著降低提示抑郁症患者在前扣带皮质及其相邻部位自发神经活动异常。
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| 关 键 词： | 抑郁症 功能磁共振 静息态 前扣带皮质 |
Brain Functions in Major Depressive Disorder:A Resting-state Functional Magnetic Resonance Imaging Study |
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| Li Dongming Huang Xiaoqi Wu Qizhu Zou Ke Sun Xueli Gong Qiyong,West China Hospital,Sichuan University,Chengdu ,China.Brain Functions in Major Depressive Disorder:A Resting-state Functional Magnetic Resonance Imaging Study[J].Journal of Biomedical Engineering,2010(1). |
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| Authors: | Li Dongming Huang Xiaoqi Wu Qizhu Zou Ke Sun Xueli Gong Qiyong West China Hospital Sichuan University Chengdu China |
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| Institution: | Li Dongming1 Huang Xiaoqi1 Wu Qizhu1 Zou Ke2 Sun Xueli2 Gong Qiyong11(Huaxi MR Research Center(HMRRC),West China Hospital,Sichuan University,Chengdu 610041,China)2(Department of Psychology,China) |
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| Abstract: | This study sought to reveal the difference in resting-state brain functions between subjects with major depressive disorder and normal controls.Fiftythree depressed patients diagnosed with DSM-IV and 38 normal controls underwent resting-state functional magnetic resonance imaging(fMRI),and the data were analyzed using a new method called Regional Homogeneity(ReHo).Then voxel wised comparison was made to derive the resting-state brain function differences between groups.Compared with normal controls,depresse... |
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| Keywords: | Depressive disorder Functional magnetic resonance imaging(fMRI) Resting-state Anterior cingulate cortex(ACC) |
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