壳聚糖微球释药机制的研究

为了探讨壳聚糖缓释微球的释药机制，制备了碳铂壳聚糖缓释微球，并对制备的微球进行了释药机制的研究。结果：制备10％碳铂壳聚缓释微球的释药80％的时间为14d，形态学的观察显示初期壳聚糖缓微球球面光整，表面无结晶，在释药14d后98％的球形仍保持完整，证明壳聚糖缓释微球的刚性良好，扫描电子显微镜检查发现，微球的外壳首先脱落出现“脱皮现象”，然后药物晶体过溶渗作用在微球表面形成众多微孔，将包封在微球内部的药物逐渐释放。结论：壳聚糖缓释微球的控释能力极强，其包封的碳铂药物晶体是通过溶渗作用逐渐释放出微球的，在90％的药物释出后，微球仍保持完整，显示了微球具有更大的包封药物的能力。

The Research of Delivery Mechanism of Chitoson Polymer Microsphere

Objective: the chitoson polymer microsphere carrying carboplatin was made to investigated the delivery mechanism of chitoson polymer microsphere. . Method: using chitoson as polymer carrier through the technique of chemical connection and, we got the kind of microsphere which has ideal drug holding. Then, the scanning electron microscopy was used to investigate the microsphere. Results: the character of drug, function of carrier, kind of skeleton, drug place and distribution in the microsphere, interaction of drug and skeleton, room of skeleton and bending of holes influenced the delivery mechanism of microsphere. The shapes of chitoson polymer microspheres which carried with or without carboplatin were different.. That the chitoson polymer microaphere which carried with carboplatin shelled had more and more tittle hole could be observed on the microsphere, but there was not the phenomenon for the microsphere without carboplatin . Conclusion: the chitoson polymer microsphere carrying carboplatin releases drug from microsphere through liquefaction and infiltration, but not through the biodegradation .