| 脂联素在非酒精性脂肪肝中的作用及机制 |
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| 引用本文： | 张征波,孙晓琦,钱斐,薛博瑜. 脂联素在非酒精性脂肪肝中的作用及机制[J]. 世界华人消化杂志, 2011, 0(19) |
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| 作者姓名： | 张征波 孙晓琦 钱斐 薛博瑜 |
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| 作者单位： | 南京中医药大学第一临床医学院; |
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| 基金项目： | 江苏省科技计划基金资助项目,No.BS2002036~~ |
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| 摘 要： | 脂联素是由脂肪细胞分泌的胰岛素敏感性脂肪因子,其对非酒精性脂肪肝病(NAFLD)有多种有益作用.在循环中脂联素有3种低聚亚型,包括三聚体、六聚体及高分子量低聚复合物.脂联素通过与靶器官上脂联素受体结合来发挥效应,其保肝作用已经在临床和实验室研究中证明.脂联素的下降是NAFLD及肝脏功能损害的独立危险因素.在动物实验中,通过药物或基因疗法使循环中的脂联素增高可导致肝肿大、脂肪变、坏死炎症及其相关肝脏疾病.脂联素敲除的小鼠,会发生肝脂肪变和线粒体功能损害,这致使小鼠易于遭受脂肪肝病的二次打击.本文旨在综述近年来对于脂联素在NAFLD中的保肝作用及机制的研究成果.
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| 关 键 词： | 脂联素 非酒精性脂肪肝 非酒精性脂肪性肝炎 胰岛素抵抗 |
Role of adiponectin in the pathogenesis and treatment of nonalcoholic fatty liver disease |
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| Zheng-Bo Zhang,Xiao-Qi Sun,Fei Qian,Bo-Yu Xue,the First Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing ,Jiangsu Province,China. Role of adiponectin in the pathogenesis and treatment of nonalcoholic fatty liver disease[J]. World Chinese Journal of Digestology, 2011, 0(19) |
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| Authors: | Zheng-Bo Zhang Xiao-Qi Sun Fei Qian Bo-Yu Xue the First Clinical Medical College Nanjing University of Chinese Medicine Nanjing Jiangsu Province China |
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| Affiliation: | Zheng-Bo Zhang,Xiao-Qi Sun,Fei Qian,Bo-Yu Xue,the First Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing 210046,Jiangsu Province,China |
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| Abstract: | Adiponectin is an insulin-sensitizing adipokine possessing multiple beneficial effects on non-alcoholic fatty liver disease.This adipokine is secreted from adipocytes into the circulation as three oligomeric isoforms:trimer,hexamer and the high molecular weight(HMW)oligomeric complex.Adiponectin binds to its receptor to exert its effects on target organs.The hepato-protective activities of adiponectin have been demonstrated by many clinical and experimental studies.Decreased level of serum adiponectin repre... |
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| Keywords: | Adiponectin Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Insulin resistance |
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