激光共焦显微镜对LASIK术后角膜组织改变的临床观察

目的应用激光共焦显微镜观察准分子激光原位角膜磨镶术（LASIK）术后角膜组织的形态学改变。方法选择2007年3月至2007年9月行LASIK手术的患者60例（118只眼）,年龄（23.8±38.2）岁（18～37岁）,术前球镜（-2.75±9.12）D,并分别于术前、术后1周、1个月、3个月、6个月、1年分别作激光共焦显微镜检查。结果 LASIK术后角膜基质细胞数量上与术前比较,无统计学意义上差异（F=1.76,P〉005）,术后角膜层间远期异常颗粒长期存在,且随时间延长而减少;中央角膜可见低细胞区,中央角膜神经纤维能够达到形态学修复。结论 LASIK术后远期角膜稳定性未见明显改变,该术式安全可行。

Evaluation of cornea organizational change after LASIK with confocal microscopy

Objective To morphologically observe the changes of corneal tissue a long period after myopic LASIK with confocal microscopy.Methods 60 patients（118eyes） from March 2006 to March 2007,who had undertook LASIK in our hospital,were involved in present study.The confocal microscopy was employed to examine the changes of cornea tissue.The average spherical equivalence was-2.75 ± 9.12 D.The average of the patients was 23.8 ± 38.2（ranged from 18 to 37）.Results There was no significant difference between pre-and post-operation keratocytes in anterior stroma inquantitatively（F = 1.76,P 0.05）.The density of high reflective particles decrease significantly with time.The appearance of morphology of subbasel corneal nerve fiber bundles after operation recovered.Conclusion Morphologic changes were found incentral cornea.Acellular area,micro-folds as well as variously reflectivity particles located at the interface in all eyes existed in the central cornea for long time.