肺鳞癌组织中淋巴管密度和纵隔淋巴结转移的关系

目的探讨肺鳞癌组织中淋巴管密度和纵隔淋巴结转移的关系.方法肺鳞癌纵隔淋巴结无转移组22例,肺鳞癌纵隔淋巴结转移组18例,肺炎性假瘤组10例.用LYVE-1/CD34免疫组化双染色法区分淋巴管和血管并观察淋巴管内皮透明质酸受体-1(LYVE-1)蛋白表达的情况,并与手术纵隔淋巴结清扫病理结果相比较.结果肺鳞癌组织周边部淋巴管密度远大于内部和炎性假瘤组织.肺鳞癌组织内部淋巴管和炎性假瘤组织淋巴管密度相似.肺鳞癌组织周边部淋巴管密度纵隔淋巴结转移组大于无纵隔淋巴结转移组.肺鳞癌组织内部淋巴管密度纵隔淋巴结转移组和无纵隔淋巴结转移组相似.结论肺鳞癌组织淋巴管生成主要在周边部,肺鳞癌细胞主要经过原发灶周边部增生的淋巴管转移至纵隔淋巴结.

Relationship between mediastinal lymph node metastasis and density of lymphoducts in pulmonary squamous cell carcinoma

Objective:To investigate the relationship between the mediastinal lymph node metastasis and the distribution and density of lymphoducts in pulmonary squamous cell carcinoma.Methods:In18cases of pulmonary squamous cell carcinoma having mediastinal lymph node metastasis,22cases of pulmonary squa-mous cell carcinoma having no mediastinal lymph node metastasis and10cases of pulmonary poroma,double immunohistochemical staining for LYVE-1/CD34was performed to distinguish lymphoducts from blood vessels,and observe the lymphatic vessel endothelial HA receptor-1(LYVE-1)manifestation,then the density of lym-phoducts was compared with the pathological report of mediastinal lymph node dissection.Results:The densi-ty of lymphatic vessels was elevated in the perimeter of the pulmonary squamous cell carcinoma tissue rela-tive to the interior and the pulmonary inflammatory pseudotumor.The density of lymphatic vessels in the inte-rior of the pulmonary squamous cell carcinoma tissue was similar to that of pulmonary inflammatory pseudotu-mor.The density of lymphatic vessels in the perimeter of the pulmonary squamous cell carcinoma with medi-astinal lymph node metastasis was higher than that of the pulmonary squamous cell carcinoma with no medi-astinal lymph node metastasis.The density of lymphatic vessels in the interior of the pulmonary squamous cell carcinoma with mediastinal lymph node metastasis was similar to that of the pulmonary squamous cell carcinoma with no mediastinal lymph node metastasis.Conclusions:The formation of lymphoducts is mainly in the perimeter of the pulmonary squamous cell carcinoma tissue.Tumor cells of the pulmonary squamous cell carcinoma mainly disseminate to the mediastinal lymph nodes through the proliferative lymphoducts in the perimeter of the pulmonary squamous cell carcinoma.