支气管肺发育不良管理中糖皮质激素选择的循证依据与个体化

尽管超早产儿存活率明显提高,支气管肺发育不良( bronchopulmonary dysplasia,BPD)始终是早产儿主要疾病及影响至成年呼吸和神经健康的最常见并发症,可持续至成年并影响呼吸及神经系统发育。糖皮质激素明显有益于BPD,但用于BPD的防治中还有许多争议,应参考已有的研究结果并结合新生儿临床特点谨慎应用。

Evidence-based and individual corticosteroids therapies for bronchopulmonary dysplasia

Despite survival of extremely preterm infants has increased over recent years,bronchopul-monary dysplasia( BPD) remains both a major cause of mortality and one of the most common complications with implications into adulthood on respiratory and neurologic health. Steroids have a clear beneficial effect on BPD,but there is much debate surrounding the use of corticosteroids on the prevention and treatment of BPD. Careful consideration of the available data along with the clinical characteristics of the individual infant is required before being introduced into therapy.