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| 麻风病血清流行病学调查与化学预防的实施 | |
| 引用本文： | 温艳,刘健,张连华,潘江武,杨寿先,李桓英,翁小满. 麻风病血清流行病学调查与化学预防的实施[J]. 中国麻风皮肤病杂志, 2008, 24(10) |
| 作者姓名： | 温艳 刘健 张连华 潘江武 杨寿先 李桓英 翁小满 |
| 作者单位： | 1. 首都医科大学附属北京友谊医院北京热带医学研究所,100050 2. 江苏省疾病预防控制中心,210009 3. 云南省文山州丘北县皮肤病防治站,663200 |
| 摘 要： | 目的:评价化学预防的保护性,本研究依据血清流行病学调查,对两个麻风病高流行村麻风病接触者和一般人群实施利福平化学预防.方法:采用临床查体、检测血清酚糖脂-1(PGL-Ⅰ)抗体和鼻分泌物麻风菌,了解人群的麻风菌感染状况,为评价预防治疗效果提供科学依据.结果:YG村临床普查率达98%,发现早期病人2例;接触者血清PGL-Ⅰ抗体阳性率76%,麻风菌鼻携带率35%,预防服药率达98%.HG村临床普查率91%,发现早期病人1例,人群血清PGL-Ⅰ抗体受检率54%,其中血清PGL-Ⅰ抗体阳性率33%,服药率达85%.结论:对亚临床感染率较高的人群实施化学预防很有必要.预防后的发病率与血清学等实验室数据可为评价预防治疗提供依据. |
| 关 键 词： | 麻风病 化学预防 PGL-Ⅰ抗体 麻风菌鼻携带 |
Serous epidemiological investigation of leprosy and evaluation of the chemoprophylaxis |
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| Wen Yan,Liu Jian,Zhang Lianhua,et al.. Serous epidemiological investigation of leprosy and evaluation of the chemoprophylaxis[J]. China Journal of Leprosy and Skin Diseases, 2008, 24(10) | |
| Authors: | Wen Yan Liu Jian Zhang Lianhua et al. |
| Affiliation: | Wen Yan,Liu Jian,Zhang Lianhua,et al. Capital University of Medicine affiliated Beijing Friendship Hospital,Beijing Tropical Medicine Institute,Beijing,100050 |
| Abstract: | Objective:Chemoprophylaxis with rifampicin (RFP) is administrated to all contacts and general population in the two endemic villages based on serum epidemiological investigation of leprosy for evaluation of protection of chemoprophylaxis. Methods: Clinical examination, detection of phenolic glycolipid-1 (PGL-I) antibody in sera and M. leprae in nasal secretion were applied for all people to understand infection with M. leprae in general population of endemic villages and providing the evidence for evaluatio... |
| Keywords: | leprosy chemoprophylaxis PGL-I antibody M. leprae nasal carriage |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |